Reference - Detail
| RRC ID | 59531 |
|---|---|
| Author | Lee HJ, Noormohammadi A, Koyuncu S, Calculli G, Simic MS, Herholz M, Trifunovic A, Vilchez D. |
| Title | Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans. |
| Journal | Nat Metab |
| Abstract |
A moderate reduction of body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germ line fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germ stem cells (GSCs) in Caenorhabditis elegans, a process modulated by thermosensory neurons. Notably, robust self-renewal of adult GSCs delays reproductive aging and is required for extended lifespan at cold temperatures. These cells release prostaglandin E2 (PGE2) to induce cbs-1 expression in the intestine, increasing somatic production of hydrogen sulfide (H2S), a gaseous signaling molecule that prolongs lifespan. Whereas loss of adult GSCs reduces intestinal cbs-1 expression and cold-induced longevity, application of exogenous PGE2 rescues these phenotypes. Importantly, tissue-specific intestinal overexpression of cbs-1 mimics cold-temperature conditions and extends longevity even at warm temperatures. Thus, our results indicate that GSCs communicate with somatic tissues to coordinate extended reproductive capacity with longevity. |
| Volume | 1(8) |
| Pages | 790-810 |
| Published | 2019-8-1 |
| DOI | 10.1038/s42255-019-0097-9 |
| PII | 10.1038/s42255-019-0097-9 |
| PMID | 31485561 |
| PMC | PMC6726479 |
| MeSH | Animals Caenorhabditis elegans / physiology* Longevity / physiology* Prostaglandins / metabolism* Signal Transduction* Stem Cells / metabolism* |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 84 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm483 |