論文 - 詳細
| RRC ID | 59532 |
|---|---|
| 著者 | Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K. |
| タイトル | A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. |
| ジャーナル | Elife |
| Abstract |
Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Here, we show that ztf-11 (Zinc-finger Transcription Factor-11), the sole Caenorhabditis elegans Myt1 homolog, is required for neurogenesis in multiple neuronal lineages from previously differentiated epithelial cells, including a neuron generated by a developmental epithelial-to-neuronal transdifferentiation event. ztf-11 is exclusively expressed in all neuronal precursors with remarkable specificity at single-cell resolution. Loss of ztf-11 leads to upregulation of non-neuronal genes and reduced neurogenesis. Ectopic expression of ztf-11 in epidermal lineages is sufficient to produce additional neurons. ZTF-11 functions together with the MuvB corepressor complex to suppress the activation of non-neuronal genes in neurons. These results dovetail with the ability of Myt1l (Myt1-like) to drive neuronal transdifferentiation in vitro in vertebrate systems. Together, we identified an evolutionarily conserved mechanism to specify neuronal cell fate by repressing non-neuronal genes. |
| 巻・号 | 8 |
| 公開日 | 2019-8-6 |
| DOI | 10.7554/eLife.46703 |
| PII | 46703 |
| PMID | 31386623 |
| PMC | PMC6684318 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism* Cell Differentiation* Epithelial Cells / physiology* Gene Expression Regulation* Neurons / physiology* Trans-Activators / metabolism* Transcription Factors |
| IF | 7.551 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2315 tm5674 tm1768 tm4063 tm2061 tm1276 |