論文 - 詳細
| RRC ID | 5954 |
|---|---|
| 著者 | Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y, Shimauchi H. |
| タイトル | Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial. |
| ジャーナル | J Clin Periodontol |
| Abstract |
AIM:This study was designed to evaluate whether the oral administration of lactobacilli could change the bacterial population in supra/subgingival plaque. MATERIAL AND METHODS:Sixty-six healthy volunteers without severe periodontitis were randomized into two groups to receive lactobacilli or placebo for 8 weeks (8W): the test group (n=34) received 2.01 x 10(9) CFU/day of Lactobacillus salivarius WB21 and xylitol in tablets; the control group (n=32) received placebo with xylitol. Supra/subgingival plaque samples were collected at the baseline and after 4 weeks (4W) and 8W. The bacterial amounts in plaque samples were analysed by quantitative real-time polymerase chain reaction. RESULTS:The numerical sum of five selected periodontopathic bacteria in the test group was decreased significantly in subgingival plaque at 4W [odds ratio (OR)=3.13, 95% confidence intervals (CI)=1.28-7.65, p=0.012]. Multivariate analysis showed that significantly higher odds were obtained for the reduction of Tannerella forsythia in subgingival plaque of the test group at both 4W (OR=6.69, 95% CI=2.51-17.9, p<0.001) and 8W (OR=3.67, 95% CI=1.45-9.26, p=0.006). CONCLUSION:Oral administration of probiotic lactobacilli reduced the numerical sum of five selected periodontopathic bacteria and could contribute to the beneficial effects on periodontal conditions. |
| 巻・号 | 36(6) |
| ページ | 506-13 |
| 公開日 | 2009-6-1 |
| DOI | 10.1111/j.1600-051X.2009.01392.x |
| PII | CPE1392 |
| PMID | 19453574 |
| MeSH | Adult Aggregatibacter actinomycetemcomitans / isolation & purification Bacteroides / isolation & purification Colony Count, Microbial Dental Plaque / microbiology Dental Plaque Index Double-Blind Method Female Follow-Up Studies Gingival Hemorrhage / microbiology Humans Lactobacillus* Male Middle Aged Periodontal Index Periodontal Pocket / microbiology Periodontitis / microbiology* Placebos Porphyromonas gingivalis / isolation & purification Prevotella intermedia / isolation & purification Probiotics / administration & dosage Probiotics / therapeutic use* Smoking Tablets Treponema denticola / isolation & purification Xylitol |
| IF | 5.241 |
| 引用数 | 70 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE |
| リソース情報 | |
| 一般微生物 | JCM 2434 JCM 8525 JCM 5225 JCM 8525 |