論文 - 詳細
| RRC ID | 59550 |
|---|---|
| 著者 | McClanahan PD, Dubuque JM, Kontogiorgos-Heintz D, Habermeyer BF, Xu JH, Ma AM, Raizen DM, Fang-Yen C. |
| タイトル | A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress. |
| ジャーナル | Sci Rep |
| Abstract |
An animal's behavioral and physiological response to stressors includes changes to its responses to stimuli. How such changes occur is not well understood. Here we describe a Caenorhabditis elegans quiescent behavior, post-response quiescence (PRQ), which is modulated by the C. elegans response to cellular stressors. Following an aversive mechanical or blue light stimulus, worms respond first by briefly moving, and then become more quiescent for a period lasting tens of seconds. PRQ occurs at low frequency in unstressed animals, but is more frequent in animals that have experienced cellular stress due to ultraviolet light exposure as well as in animals following overexpression of epidermal growth factor (EGF). PRQ requires the function of the carboxypeptidase EGL-21 and the calcium-activated protein for secretion (CAPS) UNC-31, suggesting it has a neuropeptidergic mechanism. Although PRQ requires the sleep-promoting neurons RIS and ALA, it is not accompanied by decreased arousability, and does not appear to be homeostatically regulated, suggesting that it is not a sleep state. PRQ represents a simple, tractable model for studying how neuromodulatory states like stress alter behavioral responses to stimuli. |
| 巻・号 | 10(1) |
| ページ | 4140 |
| 公開日 | 2020-3-5 |
| DOI | 10.1038/s41598-020-60994-4 |
| PII | 10.1038/s41598-020-60994-4 |
| PMID | 32139752 |
| PMC | PMC7057961 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Epidermal Growth Factor / genetics Epidermal Growth Factor / metabolism Mechanotransduction, Cellular / physiology Neurons / metabolism Neurons / radiation effects Neuropeptides / genetics Neuropeptides / metabolism Ultraviolet Rays |
| IF | 4.011 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3287 |