RRC ID 59550
Author McClanahan PD, Dubuque JM, Kontogiorgos-Heintz D, Habermeyer BF, Xu JH, Ma AM, Raizen DM, Fang-Yen C.
Title A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress.
Journal Sci Rep
Abstract An animal's behavioral and physiological response to stressors includes changes to its responses to stimuli. How such changes occur is not well understood. Here we describe a Caenorhabditis elegans quiescent behavior, post-response quiescence (PRQ), which is modulated by the C. elegans response to cellular stressors. Following an aversive mechanical or blue light stimulus, worms respond first by briefly moving, and then become more quiescent for a period lasting tens of seconds. PRQ occurs at low frequency in unstressed animals, but is more frequent in animals that have experienced cellular stress due to ultraviolet light exposure as well as in animals following overexpression of epidermal growth factor (EGF). PRQ requires the function of the carboxypeptidase EGL-21 and the calcium-activated protein for secretion (CAPS) UNC-31, suggesting it has a neuropeptidergic mechanism. Although PRQ requires the sleep-promoting neurons RIS and ALA, it is not accompanied by decreased arousability, and does not appear to be homeostatically regulated, suggesting that it is not a sleep state. PRQ represents a simple, tractable model for studying how neuromodulatory states like stress alter behavioral responses to stimuli.
Volume 10(1)
Pages 4140
Published 2020-3-5
DOI 10.1038/s41598-020-60994-4
PII 10.1038/s41598-020-60994-4
PMID 32139752
PMC PMC7057961
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Epidermal Growth Factor / genetics Epidermal Growth Factor / metabolism Mechanotransduction, Cellular / physiology Neurons / metabolism Neurons / radiation effects Neuropeptides / genetics Neuropeptides / metabolism Ultraviolet Rays
IF 4.011
Resource
C.elegans tm3287