RRC ID 59557
著者 Moore RS, Kaletsky R, Murphy CT.
タイトル Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance.
ジャーナル Cell
Abstract The ability to inherit learned information from parents could be evolutionarily beneficial, enabling progeny to better survive dangerous conditions. We discovered that, after C. elegans have learned to avoid the pathogenic bacteria Pseudomonas aeruginosa (PA14), they pass this learned behavior on to their progeny, through either the male or female germline, persisting through the fourth generation. Expression of the TGF-β ligand DAF-7 in the ASI sensory neurons correlates with and is required for this transgenerational avoidance behavior. Additionally, the Piwi Argonaute homolog PRG-1 and its downstream molecular components are required for transgenerational inheritance of both avoidance behavior and ASI daf-7 expression. Animals whose parents have learned to avoid PA14 display a PA14 avoidance-based survival advantage that is also prg-1 dependent, suggesting an adaptive response. Transgenerational epigenetic inheritance of pathogenic learning may optimize progeny decisions to increase survival in fluctuating environmental conditions.
巻・号 177(7)
ページ 1827-1841.e12
公開日 2019-6-13
DOI 10.1016/j.cell.2019.05.024
PII S0092-8674(19)30552-5
PMID 31178117
PMC PMC7518193
MeSH Animals Argonaute Proteins* / genetics Argonaute Proteins* / metabolism Avoidance Learning* Behavior, Animal* Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Epigenesis, Genetic* Pseudomonas aeruginosa Transforming Growth Factor beta* / genetics Transforming Growth Factor beta* / metabolism
IF 36.216
引用数 20
リソース情報
線虫 tm1200 tm1231