論文 - 詳細
| RRC ID | 59577 |
|---|---|
| 著者 | Rajan M, Anderson CP, Rindler PM, Romney SJ, Ferreira Dos Santos MC, Gertz J, Leibold EA. |
| タイトル | NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling. |
| ジャーナル | Elife |
| Abstract |
Iron is essential for survival of most organisms. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In C. elegans, iron uptake and sequestration are regulated by HIF-1. We previously showed that hif-1 mutants are developmentally delayed when grown under iron limitation. Here we identify nhr-14, encoding a nuclear receptor, in a screen conducted for mutations that rescue the developmental delay of hif-1 mutants under iron limitation. nhr-14 loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in hif-1 mutants. nhr-14 mutants display increased expression of innate immune genes and DAF-16/FoxO-Class II genes, and enhanced resistance to Pseudomonas aeruginosa. These responses are dependent on the transcription factor PQM-1, which localizes to intestinal cell nuclei in nhr-14 mutants. Our data reveal how C. elegans utilizes nuclear receptors to regulate innate immunity and iron availability, and show iron sequestration as a component of the innate immune response. |
| 巻・号 | 8 |
| 公開日 | 2019-9-18 |
| DOI | 10.7554/eLife.44674 |
| PII | 44674 |
| PMID | 31532389 |
| PMC | PMC6777940 |
| MeSH | Animals Biological Transport Caenorhabditis elegans / immunology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / metabolism* Disease Resistance Immunity, Innate* Iron / metabolism* Pseudomonas Infections / immunology Pseudomonas aeruginosa / immunology* Receptors, Cytoplasmic and Nuclear / metabolism* Signal Transduction* Trace Elements / metabolism Trans-Activators / metabolism* Transcription Factors / metabolism* |
| IF | 7.551 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1473 |