| RRC ID |
59583
|
| 著者 |
Rohožková J, Hůlková L, Fukalová J, Flachs P, Hozák P.
|
| タイトル |
Pairing of homologous chromosomes in C. elegans meiosis requires DEB-1 - an orthologue of mammalian vinculin.
|
| ジャーナル |
Nucleus
|
| Abstract |
During meiosis, homologous chromosomes undergo a dramatic movement in order to correctly align. This is a critical meiotic event but the molecular properties of this 'chromosomal dance' still remainunclear. We identified DEB-1 - an orthologue of mammalian vinculin - as a new component of the mechanistic modules responsible for attaching the chromosomes to the nuclear envelope as apart of the LINC complex. In early meiotic nuclei of C. elegans, DEB-1 is localized to the nuclear periphery and alongside the synaptonemal complex of paired homologues. Upon DEB-1 depletion, chromosomes attached to SUN-1 foci remain highly motile until late pachytene. Although the initiation of homologue pairing started normally, irregularities in the formation of the synaptonemal complex occur, and these results in meiotic defects such as increased number of univalents at diakinesis and high embryonic lethality. Our data identify DEB-1 as a new player regulating chromosome dynamics and pairing during meiotic prophase I.
|
| 巻・号 |
10(1)
|
| ページ |
93-115
|
| 公開日 |
2019-12-1
|
| DOI |
10.1080/19491034.2019.1602337
|
| PMID |
31068058
|
| PMC |
PMC6527391
|
| MeSH |
Animals
Caenorhabditis elegans / genetics*
Chromosome Pairing / genetics*
Chromosomes / genetics*
Meiosis / genetics*
Vinculin / genetics*
|
| IF |
2.157
|
| 引用数 |
0
|
| リソース情報 |
| 線虫 |
tm611 |
