Reference - Detail
| RRC ID | 59587 |
|---|---|
| Author | Sakai Y, Hanafusa H, Pastuhov SI, Shimizu T, Li C, Hisamoto N, Matsumoto K. |
| Title | TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor. |
| Journal | EMBO Rep |
| Abstract |
In Caenorhabditis elegans, the JNK MAP kinase (MAPK) pathway is important for axon regeneration. The JNK pathway is activated by a signaling cascade consisting of the growth factor SVH-1 and its receptor tyrosine kinase SVH-2. Expression of the svh-2 gene is induced by axonal injury in a process involving the transcription factors ETS-4 and CEBP-1. Here, we find that svh-14/mxl-1, a gene encoding a Max-like transcription factor, is required for activation of svh-2 expression in response to axonal injury. We show that MXL-1 binds to and inhibits the function of TDPT-1, a C. elegans homolog of mammalian tyrosyl-DNA phosphodiesterase 2 [TDP2; also called Ets1-associated protein II (EAPII)]. Deletion of tdpt-1 suppresses the mxl-1 defect, but not the ets-4 defect, in axon regeneration. TDPT-1 induces SUMOylation of ETS-4, which inhibits ETS-4 transcriptional activity, and MXL-1 counteracts this effect. Thus, TDPT-1 interacts with two different transcription factors in axon regeneration. |
| Volume | 20(10) |
| Pages | e47517 |
| Published | 2019-10-4 |
| DOI | 10.15252/embr.201847517 |
| PMID | 31393064 |
| PMC | PMC6776894 |
| MeSH | Animals Axons / physiology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / metabolism Gene Expression Regulation Models, Biological Motor Neurons / metabolism Nerve Regeneration* Phosphoric Diester Hydrolases / metabolism* Phosphorylation Protein Binding Proto-Oncogene Proteins c-ets / metabolism* Sumoylation* Transcription Factors / metabolism* Transcription, Genetic |
| IF | 8.383 |
| Times Cited | 0 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1530 tm737 tm311 tm2610 |