論文 - 詳細
| RRC ID | 59607 |
|---|---|
| 著者 | Takagaki N, Ohta A, Ohnishi K, Kawanabe A, Minakuchi Y, Toyoda A, Fujiwara Y, Kuhara A. |
| タイトル | The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. |
| ジャーナル | EMBO Rep |
| Abstract |
Caenorhabditis elegans mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by mechanoreceptor-mediated circuit calculation. |
| 巻・号 | 21(3) |
| ページ | e48671 |
| 公開日 | 2020-3-4 |
| DOI | 10.15252/embr.201948671 |
| PMID | 32009302 |
| PMC | PMC7054665 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cold Temperature* Humans Mechanoreceptors / metabolism Membrane Proteins Sensory Receptor Cells / metabolism Sodium Channels |
| IF | 8.383 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm7280 tm10725 tm5192 tm2994 tm1163 tm3455 tm4022 tm7132 tm3007 tm1987 tm6528 tm776 tm3294 |