論文 - 詳細
| RRC ID | 59624 |
|---|---|
| 著者 | Wu T, Duan F, Yang W, Liu H, Caballero A, Fernandes de Abreu DA, Dar AR, Alcedo J, Ch'ng Q, Butcher RA, Zhang Y. |
| タイトル | Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides. |
| ジャーナル | Neuron |
| Abstract |
Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act respectively in the pheromone-sensing neuron ADL and the bacteria-sensing neuron AWA. Pheromone exposure inhibits learning by disrupting this balance: it activates ADL and increases expression of ins-16, and this cellular effect reduces AWA activity and AWA-expressed ins-4. The activities of the sensory neurons are required for learning and the expression of the ILPs. Interestingly, pheromones also promote the ingestion of pathogenic bacteria while increasing resistance to the pathogen. Thus, the balance of the ILP signals integrates social information into the learning process as part of a coordinated adaptive response that allows consumption of harmful food during times of high population density. |
| 巻・号 | 104(6) |
| ページ | 1095-1109.e5 |
| 公開日 | 2019-12-18 |
| DOI | 10.1016/j.neuron.2019.09.006 |
| PII | S0896-6273(19)30779-2 |
| PMID | 31676170 |
| PMC | PMC7009321 |
| MeSH | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism* Feeding Behavior / physiology Insulins / metabolism* Learning / physiology* Pheromones / metabolism* Sensory Receptor Cells / physiology Signal Transduction / physiology |
| IF | 14.403 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4467 tm3608 tm3620 tm2560 tm4144 tm1875 tm2988 tm6467 tm2001 tm2416 |