RRC ID 59630
著者 Yue Y, Shen P, Chang AL, Qi W, Kim KH, Kim D, Park Y.
タイトル trans-Trismethoxy resveratrol decreased fat accumulation dependent on fat-6 and fat-7 in Caenorhabditis elegans.
ジャーナル Food Funct
Abstract trans-Trismethoxy resveratrol (TMR) is a methyl analog of resveratrol. It is found to exhibit enhanced biological effects compared to resveratrol, such as inhibition of cancer cell growth and pro-apoptotic activities. However, the role of TMR in lipid metabolism is not fully understood. In this study, we used Caenorhabditis elegans, an in vivo nematode model which has been widely applied in disease research, including research on obesity, to investigate the effect of TMR on lipid metabolism. Treatment with TMR (100 and 200 μM) for 4 days significantly reduced triglyceride accumulation (14% and 20% reduction over the control, respectively) of C. elegans, without affecting nematode growth, food intake and reproduction. Treatment with TMR significantly downregulated stearoyl-CoA desaturase genes, fat-6 and fat-7, accompanied by a decrease in the desaturation index of fatty acids, the ratio of oleic acid to stearic acid. These results suggest that TMR inhibits fat accumulation by downregulating stearoyl-CoA desaturase in C. elegans.
巻・号 10(8)
ページ 4966-4974
公開日 2019-8-1
DOI 10.1039/c9fo00778d
PMID 31343008
MeSH Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Fats / metabolism* Fatty Acid Desaturases / genetics Fatty Acid Desaturases / metabolism* Resveratrol / chemistry Resveratrol / pharmacology* Stearoyl-CoA Desaturase / genetics Stearoyl-CoA Desaturase / metabolism* Triglycerides / metabolism
IF 3.241
引用数 1
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