| RRC ID |
59667
|
| Author |
Fujita K, Somiya M, Kuroda S, Hinuma S.
|
| Title |
Induction of lipid droplets in non-macrophage cells as well as macrophages by liposomes and exosomes.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
It has been reported that phospholipid nanoparticles (PNPs) including liposomes and exosomes could efficiently induce lipid droplets (LDs) in macrophages. However, in non-macrophage cells, the effects of PNPs on the induction of LDs have not been thoroughly investigated. In this report, we directly compared non-macrophage and macrophage cell lines in terms of LD induction by various formulation of liposomes containing phosphatidylserine and exosomes. All non-macrophage cell lines as well as macrophage cell lines tested in this study showed evident LD induction in response to these PNPs, though the efficacy of LD induction in non-macrophage cell lines varied considerably. Our results suggest that LD formation is a common and crucial response to PNPs in mammalian cells not only in macrophages but also in non-macrophage cells.
|
| Volume |
510(1)
|
| Pages |
184-190
|
| Published |
2019-2-26
|
| DOI |
10.1016/j.bbrc.2019.01.078
|
| PII |
S0006-291X(19)30092-0
|
| PMID |
30678809
|
| MeSH |
Animals
Cell Line
Exosomes / physiology*
Humans
Lipid Droplets / metabolism*
Liposomes / chemistry
Liposomes / pharmacology*
Macrophages / ultrastructure*
Nanoparticles / chemistry
Phosphatidylserines
Phospholipids
|
| IF |
2.705
|
| Times Cited |
1
|
| Resource |
| Human and Animal Cells |
NB2a(RCB2639)
293T(RCB2202)
RAW 264(RCB0535)
COS-7(RCB0539) |
