RRC ID 59706
Author Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S.
Title Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.
Journal Anticancer Agents Med Chem
Abstract AIMS:This study was designed to investigate the phytochemical profile and the cytotoxic activities of the eco-friendly extracts of olive leaves from Chemlali cultivar.
MATERIALS AND METHODS:The Phenolic composition of olive leaves extracts, the antioxidant activity and the cytotoxic effects against MCF-7 and HepG2 cells were determined.
RESULTS:Olive leaves extracts showed relevant total polyphenols contents. Oleuropein was the major detected phenolic compound reaching a concentration of 16.9 mg/ml. The antioxidant potential of the studied extracts varied from 23.7 to 46.5mM Trolox equivalents as revealed by DPPH and ABTS assays. Cytotoxicity experiments showed similar trends for both HepG2 and MCF-7 cells with the infusion extract being the most active.
CONCLUSION:This study denotes that olive leaves may have great potential as endless bioresource of valuable bioactive compounds which may have a wide application.
Volume 19(13)
Pages 1651-1657
Published 2019-1-1
DOI 10.2174/1871520619666190416101622
PMID 31038081
MeSH Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / pharmacology* Antioxidants / chemistry Antioxidants / pharmacology* Cell Line, Tumor Humans Olea / chemistry* Plant Extracts / pharmacology* Plant Leaves / chemistry* Polyphenols / chemistry Polyphenols / pharmacology*
IF 2.049
Times Cited 0
Human and Animal Cells MCF7(RCB1904) Hep G2(RCB1886)