論文 - 詳細
| RRC ID | 59708 |
|---|---|
| 著者 | Mizuno Y, Taguchi T. |
| タイトル | Promotion of Cell Migration into a Hydrophobically modified Alaska Pollock Gelatin-Based Hydrogel. |
| ジャーナル | Macromol Biosci |
| Abstract |
In situ chemically cross-linkable hydrogels composed of hexyl group-modified Alaska pollock-derived gelatin (C6-ApGltn) and poly(ethylene glycol)-based four-armed cross-linker is developed. Water droplets are quickly absorbed into the C6-ApGltn hydrogel in the first 10 s compared with original ApGltn (Org-ApGltn), and the final contact angle on C6-ApGltn is significantly lower than that on Org-ApGltn. Using a fluorescent probe, an increase in fluorescence intensity on C6-ApGltn compared to that on Org-ApGltn is found, indicating the formation of a hydrophobic pocket. Moreover, the promotion of cell migration into the C6-ApGltn hydrogel is observed in vitro and in vivo compared with Org-ApGltn hydrogel, despite no significant difference in elastic modulus. Therefore, the C6-ApGltn hydrogel could potentially be used as a supporting material for cell transplantation and tissue/organ engineering. |
| 巻・号 | 19(7) |
| ページ | e1900083 |
| 公開日 | 2019-7-1 |
| DOI | 10.1002/mabi.201900083 |
| PMID | 31081246 |
| MeSH | Animals Cell Movement / drug effects* Fishes Gelatin / chemical synthesis Gelatin / chemistry Gelatin / pharmacology* Human Umbilical Vein Endothelial Cells / cytology Human Umbilical Vein Endothelial Cells / drug effects Humans Hydrogels / chemistry Hydrogels / pharmacology* Hydrophobic and Hydrophilic Interactions* Mice RAW 264.7 Cells Rats, Wistar Rheology Water / chemistry |
| IF | 2.895 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | L929 |