論文 - 詳細
| RRC ID | 59721 |
|---|---|
| 著者 | Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N. |
| タイトル | Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia. |
| ジャーナル | Cells |
| Abstract |
Microglia maintain brain homeostasis and modulate neuroinflammation and are implicated in the pathogenesis of various neurological diseases such as Alzheimer's disease. In this study, we found that in lipopolysaccharide (LPS)-stimulated microglia, the endoplasmic reticulum (ER) stress-related eIF-2-ATF4 pathway plays significant roles in TNF- and IL-6 production, as well as in the inflammasome-mediated production of IL-1. Furthermore, our analysis revealed that oxytocin (OT), a nonapeptide synthesized in the hypothalamus, suppressed the production of these proinflammatory cytokines by inhibiting activation of the eIF-2-ATF4 pathway. Our findings therefore suggest a novel anti-inflammatory axis of OT in activated microglia, which would be helpful for developing the novel effective strategies for regulating microglia-associated neuroinflammation. |
| 巻・号 | 8(6) |
| 公開日 | 2019-5-31 |
| DOI | 10.3390/cells8060527 |
| PII | cells8060527 |
| PMID | 31159306 |
| PMC | PMC6627458 |
| MeSH | Activating Transcription Factor 4 / metabolism* Animals Cell Line Cytokines / biosynthesis Endoplasmic Reticulum Stress / drug effects Eukaryotic Initiation Factor-2 / metabolism* Inflammasomes / drug effects Inflammasomes / metabolism Inflammation / metabolism* Inflammation / pathology* Inflammation Mediators / metabolism Lipopolysaccharides Mice Microglia / drug effects Microglia / metabolism Microglia / pathology* NF-kappa B / metabolism Oxytocin / pharmacology* Phosphorylation / drug effects Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism Signal Transduction* / drug effects p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 5.656 |
| 引用数 | 4 |
| リソース情報 | |
| ヒト・動物細胞 | MG6(RCB2403) |