RRC ID 5979
Author Zhu J, Kang Y, Uno J, Taguchi H, Liu Y, Ohata M, Tanaka R, Moretti ML, Mikami Y.
Title Comparison of genotypes between environmental and clinical isolates of Cryptococcus neoformans var. grubii based on microsatellite patterns.
Journal Mycopathologia
Abstract We applied multilocus microsatellite typing (MLMT) method to investigate the genetic relation between Cryptococcus neoformans var. grubii clinical and environmental isolates in São Paulo, Brazil. This MLMT method includes three functional gene sequences of C. neoformans var. grubii, which are dispersed on three chromosomes. In all, 89 strains (36 clinical and 53 environmental isolates) were analyzed. Of 36 clinical strains, 20 belonged to a major type of MLMT-13 (55.6%). They were mainly isolated from clinical specimens. About 52.8% of strains from the environment belong to a major type of MLMT-36, which are indigenous to environments and which were not isolated from clinical samples. Thus, we recognized two genotypes that distinguish majority of clinical and environmental strains. No differences were found in antifungal susceptibility and capsule size between major environmental and clinical MLMT types.
Volume 169(1)
Pages 47-55
Published 2010-1
DOI 10.1007/s11046-009-9230-8
PMID 19680781
MeSH Animals Antifungal Agents / pharmacology Brazil Columbidae Cryptococcosis / microbiology* Cryptococcus neoformans / cytology Cryptococcus neoformans / drug effects Cryptococcus neoformans / genetics* DNA, Fungal / analysis DNA, Fungal / genetics Environmental Microbiology* Genetic Variation Genome, Fungal HIV HIV Infections / complications Humans Microbial Sensitivity Tests Microsatellite Repeats* Sequence Analysis, DNA Species Specificity
IF 1.476
Times Cited 6
WOS Category MYCOLOGY
Resource
Pathogenic microorganisms C. neoformans(IFM 56700) (IFM 56701) (IFM 56702) (IFM 56703) (IFM 56704) (IFM 56705) (IFM 56706) (IFM 56707) (IFM 56708) (IFM 56709) (IFM 56710) (IFM 56711) (IFM 56712) (IFM 56713) (IFM 56714) (IFM 56715) (IFM 56716) (IFM 56717) (IFM 56718) (IFM 56719) (IFM 56720) (IFM 56721) (IFM 56722) (IFM 56723) (IFM 56724) (IFM 56725) (IFM 56726) (IFM 56727) (IFM 56728) (IFM 56729) (IFM 56730) (IFM 56731) (IFM 56732) (IFM 56733) (IFM 56734) (IFM 56735) (IFM 56736) (IFM 56737) (IFM 56738) (IFM 56739) (IFM 56740) (IFM 56741) (IFM 56742) (IFM 56743) (IFM 56744) (IFM 56745) (IFM 56746) (IFM 56747) (IFM 56748) (IFM 56749) (IFM 56750) (IFM 56751) (IFM 56752) (IFM 56766) (IFM 56769) (IFM 56770) (IFM 56771) (IFM 56772) (IFM 56774) (IFM 56775) (IFM 56777) (IFM 56778) (IFM 56779) (IFM 56780) (IFM 56781) (IFM 56782) (IFM 56783) (IFM 56784) IFM 56786) (IFM 56787) (IFM 56788) (IFM 56789) (IFM 56791) (IFM 56792) (IFM 56793) (IFM 56794) (IFM 56795) (IFM 56796) (IFM 56797) (IFM 56798) (IFM 56799) (IFM 56800) (IFM 56801) (IFM 56802) (IFM 56803) (IFM 56804) (IFM 56805) (IFM 56806) (IFM 56807)