Reference - Detail
| RRC ID | 59825 |
|---|---|
| Author | Li J, Yoshida Y, Kurita M, Usuki T. |
| Title | Cynaropicrin and inhibition of NF-κB activation: A structure activity relationship study. |
| Journal | Bioorg Med Chem Lett |
| Abstract |
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. This natural product has various biological activities including anti-inflammatory properties and antitrypanosomal activity. It was also found to suppress photoaging of the skin by inhibiting the transcription activity of nuclear factor-kappa B (NF-κB). In this paper, nine chemical derivatives of cynaropicrin were prepared, and the structure activity relationship (SAR) study for NF-κB inhibition by measuring relative light units (RLU) was conducted. |
| Volume | 29(12) |
| Pages | 1518-1521 |
| Published | 2019-6-15 |
| DOI | 10.1016/j.bmcl.2019.04.004 |
| PII | S0960-894X(19)30213-6 |
| PMID | 30987894 |
| MeSH | Cytotoxins / pharmacology Cytotoxins / therapeutic use* Humans Lactones / pharmacology Lactones / therapeutic use* NF-kappa B / metabolism* Sesquiterpenes / pharmacology Sesquiterpenes / therapeutic use* Structure-Activity Relationship |
| IF | 2.448 |
| Times Cited | 0 |
| Resource | |
| Human and Animal Cells | 293(RCB1637) |