| RRC ID |
59856
|
| 著者 |
Cheng BF, Lian JJ, Yang HJ, Wang L, Yu HH, Bi JJ, Gao YX, Chen SJ, Wang M, Feng ZW.
|
| タイトル |
Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis.
|
| ジャーナル |
Stem Cells Transl Med
|
| Abstract |
Chondrocyte hypertrophy-like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of mesenchymal stem cells (MSCs). In this study, we found that NCAM deficiency accelerates chondrocyte hypertrophy in articular cartilage and growth plate of OA mice. NCAM deficiency leads to hypertrophic chondrocyte differentiation in both murine MSCs and chondrogenic cells, in which extracellular signal-regulated kinase (ERK) signaling plays an important role. Moreover, NCAM expression is downregulated in an interleukin-1β-stimulated OA cellular model and monosodium iodoacetate-induced OA rats. Overexpression of NCAM substantially inhibits hypertrophic differentiation in the OA cellular model. In conclusion, NCAM could inhibit hypertrophic chondrocyte differentiation of MSCs by inhibiting ERK signaling and reduce chondrocyte hypertrophy in experimental OA model, suggesting the potential utility of NCAM as a novel therapeutic target for alleviating chondrocyte hypertrophy of OA.
|
| 巻・号 |
9(2)
|
| ページ |
273-283
|
| 公開日 |
2020-2-1
|
| DOI |
10.1002/sctm.19-0190
|
| PMID |
31742919
|
| PMC |
PMC6988767
|
| MeSH |
Animals
Cell Differentiation
Chondrocytes / metabolism*
Chondrogenesis / physiology*
Humans
Mice
Neural Cell Adhesion Molecules / metabolism*
Osteoarthritis / pathology*
Rats
Rats, Wistar
Transfection
|
| IF |
5.962
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
ATDC5(RCB0565) |
