RRC ID 59864
著者 Ishida T, Iizuka M, Ou Y, Morisawa S, Hirata A, Yagi Y, Jobu K, Morita Y, Miyamura M.
タイトル Juzentaihoto hot water extract alleviates muscle atrophy and improves motor function in streptozotocin-induced diabetic oxidative stress mice.
ジャーナル J Nat Med
Abstract A decrease in skeletal muscle mass and motor function occurs in diabetic patients. In type 1 diabetic patients, in particular, fast-type fiber-dominated muscle atrophy occurs due to increased oxidative stress and inflammation. Juzentaihoto is a herbal medicine that has been found to be effective in reducing oxidative stress. In this study, juzentaihoto hot water extract (JTT) was administered prophylactically to mice with diabetic oxidative stress, which was induced by an injection of streptozotocin, and the effects on skeletal muscle mass, motor function, and antioxidant activity were evaluated. In mice that were administered JTT, skeletal muscle atrophy and loss of motor function were suppressed. Additionally, the administration of JTT increased the mRNA expression level of Sirt1 and the activity of superoxide dismutase in the gastrocnemius. In addition to skeletal muscle atrophy, atrophy of the liver, spleen and thymus gland, and kidney hypertrophy were also suppressed. Furthermore, in order to evaluate the antioxidant activity of 10 constituent crude drugs that comprise juzentaihoto, Sirt1 transcriptional activity in C2C12 cells was evaluated. The Sirt1 transcriptional activity was increased by Cinnamomi Cortex, Astragali Radix, and Glycyrrhizae Radix extracts. These three constituent crude drugs play an important function in the antioxidant action of juzentaihoto, suggesting that juzentaihoto can prevent muscle atrophy by decreasing oxidative stress.
巻・号 73(1)
ページ 202-209
公開日 2019-1-1
DOI 10.1007/s11418-018-1269-8
PII 10.1007/s11418-018-1269-8
PMID 30478793
MeSH Animals Diabetes Mellitus, Experimental / chemically induced Diabetes Mellitus, Experimental / drug therapy* Drugs, Chinese Herbal / pharmacology Drugs, Chinese Herbal / therapeutic use* Hot Temperature Male Mice Muscular Atrophy / drug therapy* Oxidative Stress / drug effects* Phytotherapy / methods* Plant Extracts / pharmacology Plant Extracts / therapeutic use* Streptozocin / adverse effects* Water / chemistry*
IF 1.966
引用数 0
リソース情報
ヒト・動物細胞 C2C12(RCB0987)