| RRC ID |
59903
|
| 著者 |
Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.
|
| タイトル |
Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect.
|
| ジャーナル |
J Pharmacol Sci
|
| Abstract |
Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.
|
| 巻・号 |
140(3)
|
| ページ |
291-294
|
| 公開日 |
2019-7-1
|
| DOI |
10.1016/j.jphs.2019.05.009
|
| PII |
S1347-8613(19)35681-6
|
| PMID |
31377017
|
| MeSH |
Animals
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Donepezil / pharmacology*
Male
Mice
Neuroprotective Agents / pharmacology*
Oxaliplatin / pharmacology*
PC12 Cells
Peripheral Nervous System Diseases / chemically induced*
Peripheral Nervous System Diseases / drug therapy*
Rats
Rats, Sprague-Dawley
Sciatic Nerve / drug effects
|
| IF |
2.835
|
| 引用数 |
4
|
| リソース情報 |
| ヒト・動物細胞 |
HCT116(RCB2979)
MKN45(RCB1001) |
