RRC ID 59928
著者 Kutluay VM, Ishiuchi K, Makino T, Saracoglu I.
タイトル Cytotoxic phenylethanoid glycosides from Digitalis davisiana Heywood: Evaluation of structure activity relationships and chemotaxonomical significance of isolated compounds.
ジャーナル Fitoterapia
Abstract The phytochemical studies on the aerial parts of Digitalis davisiana Heywood led to the isolation of three undescribed phenylethanoid glycosides named as digidavisoside A (5), digidavisoside B (7), and davisoside (8), along with 9 known compounds, ferruginoside B (1), isolugrandoside (2), lugrandoside (3), maxoside (4), 3″″-O-methylmaxoside (6), trans-lamiuside E (9), digiciliside B (10), p-hydroxyacetophenone (11), and chrysoeriol (12). For the first time compound 11 was reported for Digitalis genus. The chemotaxonomical significance of these compounds in Plantaginaceae family was evaluated and 3'-O-glucosyl substituted phenylethanoid glycosides 4-8 and 10 were found to be chemotaxonomically important for the family. Cytotoxic activity of the aqueous fraction of the methanolic extract was also tested against HEp-2 (human larynx epidermoid carcinoma) and HepG2 (human hepatocellular carcinoma) cancer cell lines. The aqueous fraction showed stronger cytotoxicity on HEp-2 cells than on HepG2. Therefore, the cytotoxic activity of 1-4, 6, 7 and 9 were tested against HEp-2 and L929 (mouse fibroblast cell) cell lines. Other isolated compounds could not be tested due to their insufficient amount. The results were evaluated in the point of structure-activity relationships. IC50 values against HEp-2 cells were established in a range of 71.9-220 μM. Maxoside (4), isolugrandoside (2) and lugrandoside (3) showed higher cytotoxicity against HEp-2 cell line than other isolated compounds.
巻・号 135
ページ 90-98
公開日 2019-6-1
DOI 10.1016/j.fitote.2019.04.009
PII S0367-326X(19)30591-X
PMID 31014930
MeSH Animals Cell Line, Tumor Digitalis / chemistry* Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology* Humans Mice Molecular Structure Phenylethyl Alcohol / chemistry Phenylethyl Alcohol / isolation & purification Phenylethyl Alcohol / pharmacology* Phytochemicals / chemistry Phytochemicals / isolation & purification Phytochemicals / pharmacology* Plant Components, Aerial / chemistry Structure-Activity Relationship
IF 2.431
引用数 2
リソース情報
ヒト・動物細胞 HEp-2(RCB1889)