| RRC ID |
60061
|
| 著者 |
Hayashi Y, Jia W, Kidoya H, Muramatsu F, Tsukada Y, Takakura N.
|
| タイトル |
Galectin-3 Inhibits Cancer Metastasis by Negatively Regulating Integrin β3 Expression.
|
| ジャーナル |
Am J Pathol
|
| Abstract |
Galectin-3 (Gal-3; gene LGALS3) is a member of the β-galactose-binding lectin family. Previous studies showed that Gal-3 is expressed in several tissues across species and functions as a regulator of cell proliferation, apoptosis, adhesion, and migration, thus affecting many aspects of events, such as angiogenesis and tumorigenesis. Although several reports have suggested that the level of Gal-3 expression correlates positively with tumor progression, herein we show that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential. It was found that overexpression of Gal-3 in melanoma cells in fact suppresses metastasis. In contrast, knocking out Gal-3 expression in cancer cells promoted cell aggregation mediated through interactions with platelets and fibrinogen in vitro and increased the number of metastatic foci in vivo. Thus, reduced Gal-3 expression results in the up-regulation of β3 integrin expression, and this contributes to metastatic potential. These findings indicate that changes of Gal-3 expression in cancer cells during tumor progression influence the characteristics of metastatic cells.
|
| 巻・号 |
189(4)
|
| ページ |
900-910
|
| 公開日 |
2019-4-1
|
| DOI |
10.1016/j.ajpath.2018.12.005
|
| PII |
S0002-9440(18)30655-2
|
| PMID |
30653955
|
| MeSH |
Animals
Apoptosis
Cell Adhesion
Cell Proliferation
Galectin 3 / physiology*
Gene Expression Regulation, Neoplastic*
Humans
Integrin beta3 / genetics
Integrin beta3 / metabolism*
Lung Neoplasms / metabolism
Lung Neoplasms / prevention & control*
Lung Neoplasms / secondary
Melanoma, Experimental / metabolism
Melanoma, Experimental / pathology
Melanoma, Experimental / prevention & control*
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Nude
Neovascularization, Pathologic / prevention & control*
|
| IF |
3.762
|
| 引用数 |
6
|
| リソース情報 |
| ヒト・動物細胞 |
MMAc(RCB0808) |
