論文 - 詳細
| RRC ID | 60061 |
|---|---|
| 著者 | Hayashi Y, Jia W, Kidoya H, Muramatsu F, Tsukada Y, Takakura N. |
| タイトル | Galectin-3 Inhibits Cancer Metastasis by Negatively Regulating Integrin β3 Expression. |
| ジャーナル | Am J Pathol |
| Abstract |
Galectin-3 (Gal-3; gene LGALS3) is a member of the β-galactose-binding lectin family. Previous studies showed that Gal-3 is expressed in several tissues across species and functions as a regulator of cell proliferation, apoptosis, adhesion, and migration, thus affecting many aspects of events, such as angiogenesis and tumorigenesis. Although several reports have suggested that the level of Gal-3 expression correlates positively with tumor progression, herein we show that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential. It was found that overexpression of Gal-3 in melanoma cells in fact suppresses metastasis. In contrast, knocking out Gal-3 expression in cancer cells promoted cell aggregation mediated through interactions with platelets and fibrinogen in vitro and increased the number of metastatic foci in vivo. Thus, reduced Gal-3 expression results in the up-regulation of β3 integrin expression, and this contributes to metastatic potential. These findings indicate that changes of Gal-3 expression in cancer cells during tumor progression influence the characteristics of metastatic cells. |
| 巻・号 | 189(4) |
| ページ | 900-910 |
| 公開日 | 2019-4-1 |
| DOI | 10.1016/j.ajpath.2018.12.005 |
| PII | S0002-9440(18)30655-2 |
| PMID | 30653955 |
| MeSH | Animals Apoptosis Cell Adhesion Cell Proliferation Galectin 3 / physiology* Gene Expression Regulation, Neoplastic* Humans Integrin beta3 / genetics Integrin beta3 / metabolism* Lung Neoplasms / metabolism Lung Neoplasms / prevention & control* Lung Neoplasms / secondary Melanoma, Experimental / metabolism Melanoma, Experimental / pathology Melanoma, Experimental / prevention & control* Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Neovascularization, Pathologic / prevention & control* |
| IF | 3.762 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MMAc(RCB0808) |