RRC ID 60061
Author Hayashi Y, Jia W, Kidoya H, Muramatsu F, Tsukada Y, Takakura N.
Title Galectin-3 Inhibits Cancer Metastasis by Negatively Regulating Integrin β3 Expression.
Journal Am J Pathol
Abstract Galectin-3 (Gal-3; gene LGALS3) is a member of the β-galactose-binding lectin family. Previous studies showed that Gal-3 is expressed in several tissues across species and functions as a regulator of cell proliferation, apoptosis, adhesion, and migration, thus affecting many aspects of events, such as angiogenesis and tumorigenesis. Although several reports have suggested that the level of Gal-3 expression correlates positively with tumor progression, herein we show that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential. It was found that overexpression of Gal-3 in melanoma cells in fact suppresses metastasis. In contrast, knocking out Gal-3 expression in cancer cells promoted cell aggregation mediated through interactions with platelets and fibrinogen in vitro and increased the number of metastatic foci in vivo. Thus, reduced Gal-3 expression results in the up-regulation of β3 integrin expression, and this contributes to metastatic potential. These findings indicate that changes of Gal-3 expression in cancer cells during tumor progression influence the characteristics of metastatic cells.
Volume 189(4)
Pages 900-910
Published 2019-4
DOI 10.1016/j.ajpath.2018.12.005
PII S0002-9440(18)30655-2
PMID 30653955
MeSH Animals Apoptosis Cell Adhesion Cell Proliferation Galectin 3 / physiology* Gene Expression Regulation, Neoplastic* Humans Integrin beta3 / genetics Integrin beta3 / metabolism* Lung Neoplasms / metabolism Lung Neoplasms / prevention & control* Lung Neoplasms / secondary Melanoma, Experimental / metabolism Melanoma, Experimental / pathology Melanoma, Experimental / prevention & control* Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Neovascularization, Pathologic / prevention & control*
IF 3.762
Times Cited 6
Human and Animal Cells MMAc(RCB0808)