論文 - 詳細
| RRC ID | 60115 |
|---|---|
| 著者 | Sakakura A, Pauze M, Namiki A, Funakoshi-Tago M, Tamura H, Hanaya K, Higashibayashi S, Sugai T. |
| タイトル | Chemoenzymatic synthesis of hydroxytyrosol monoesters and their suppression effect on nitric oxide production stimulated by lipopolysaccharides. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Fatty acid monoesters of hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol] were synthesized in two steps from tyrosol (4-hydroxyphenylethanol) by successive Candida antarctica lipase B-catalyzed chemoselective acylation on the primary aliphatic hydroxy group over phenolic hydroxy group in tyrosol, and 2-iodoxybenzoic acid (IBX)-mediated hydroxylation adjacent to the remaining free phenolic hydroxy group. Examination of their suppression effects on nitric oxide production stimulated by lipopolysaccharides in RAW264.7 cells showed that hydroxytyrosol butyrate exhibited the highest inhibition (IC50 7.0 μM) among the tested compounds. |
| 巻・号 | 83(2) |
| ページ | 185-191 |
| 公開日 | 2019-2-1 |
| DOI | 10.1080/09168451.2018.1530970 |
| PMID | 30319060 |
| MeSH | Acylation Animals Carbon-13 Magnetic Resonance Spectroscopy Esters / chemical synthesis* Esters / chemistry Esters / pharmacology Fungal Proteins / metabolism* Hydroxylation Inhibitory Concentration 50 Lipase / metabolism* Lipopolysaccharides / pharmacology* Mice Nitric Oxide / antagonists & inhibitors* Nitric Oxide / biosynthesis* Phenylethyl Alcohol / analogs & derivatives* Phenylethyl Alcohol / chemical synthesis Phenylethyl Alcohol / chemistry Phenylethyl Alcohol / pharmacology Proton Magnetic Resonance Spectroscopy RAW 264.7 Cells Spectrometry, Mass, Electrospray Ionization |
| IF | 1.297 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |