| RRC ID |
60176
|
| 著者 |
Yamanaka H, Kadomatsu R, Takagi T, Ohsawa M, Yamamoto N, Kubo N, Takemoto T, Ohsawa K.
|
| タイトル |
Antimicrobial resistance profiles of vancomycin-resistant Enterococcus species isolated from laboratory mice.
|
| ジャーナル |
J Vet Sci
|
| Abstract |
Isolates of 24 enterococci, 5 Enterococcus casseliflavus and 19 Enterococcus gallinarum, possessing vanC genes and showing low-level resistance to vancomycin were obtained from mice from commercial mouse breeding companies. Since some of these isolates showed resistance to other antibiotics, the purpose of this study was to clarify the resistant profiles of these isolates. One E. casseliflavus isolate showed resistance to erythromycin with a minimal inhibitory concentration (MIC) of 8 μg/mL and also showed apparent resistance to fluoroquinolones with an MIC of 32 μg/mL for ciprofloxacin. The MICs of 2 other fluoroquinolone-resistant E. casseliflavus and E. gallinarum isolates were 3 and 6 μg/mL, respectively. These 3 resistant isolates showed an absence of macrolide- and fluoroquinolone-resistant genes, including amino acid substitutions in the quinolone resistance determining regions of DNA gyrase and topoisomerase IV. Resistance to tetracycline was detected in 2 E. gallinarum isolates that were highly resistant, exhibiting MICs of 48 and 64 μg/mL and possessing tet(O) genes. The results indicate that antibiotic-resistant enterococci are being maintained in some laboratory mouse strains that have never been treated with an antibiotic.
|
| 巻・号 |
20(2)
|
| ページ |
e13
|
| 公開日 |
2019-3-1
|
| DOI |
10.4142/jvs.2019.20.e13
|
| PMID |
30944535
|
| PMC |
PMC6441807
|
| MeSH |
Animals
Animals, Laboratory / microbiology*
Anti-Bacterial Agents / pharmacology
Drug Resistance, Bacterial / genetics
Enterococcus / drug effects*
Enterococcus / genetics
Enterococcus / isolation & purification
Genes, Bacterial / genetics
Mice / microbiology*
Microbial Sensitivity Tests / veterinary
Sequence Analysis, DNA / veterinary
Vancomycin Resistance / genetics
|
| IF |
1.561
|
| 引用数 |
0
|
| リソース情報 |
| 一般微生物 |
JCM1651 |
