論文 - 詳細
| RRC ID | 6027 |
|---|---|
| 著者 | Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T. |
| タイトル | Autophagy defends cells against invading group A Streptococcus. |
| ジャーナル | Science |
| Abstract |
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens. |
| 巻・号 | 306(5698) |
| ページ | 1037-40 |
| 公開日 | 2004-11-5 |
| DOI | 10.1126/science.1103966 |
| PII | 306/5698/1037 |
| PMID | 15528445 |
| MeSH | Autophagy / physiology* Colony Count, Microbial HeLa Cells Humans Immunity, Innate Lysosomes / physiology Streptococcus pyogenes / immunology* |
| IF | 41.846 |
| 引用数 | 791 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00806 |