RRC ID 6027
著者 Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T.
タイトル Autophagy defends cells against invading group A Streptococcus.
ジャーナル Science
Abstract We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.
巻・号 306(5698)
ページ 1037-40
公開日 2004-11-5
DOI 10.1126/science.1103966
PII 306/5698/1037
PMID 15528445
MeSH Autophagy / physiology* Colony Count, Microbial HeLa Cells Humans Immunity, Innate Lysosomes / physiology Streptococcus pyogenes / immunology*
IF 41.846
引用数 791
WOS 分野 CELL BIOLOGY
リソース情報
実験動物マウス RBRC00806