論文 - 詳細
RRC ID | 60289 |
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著者 | Wang Y, Hatabu T. |
タイトル | Mulberry juice freeze-dried powder attenuates the disease severity by the maintaining of colon mucosa in mice with DSS-induced acute colitis. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions. |
巻・号 | 83(5) |
ページ | 914-922 |
公開日 | 2019-5-1 |
DOI | 10.1080/09168451.2019.1580135 |
PMID | 30774006 |
MeSH | Acute Disease Animals Beverages* Colitis / drug therapy* Colitis / physiopathology Dextran Sulfate / toxicity* Freeze Drying* Intestinal Mucosa / drug effects* Intestinal Mucosa / physiopathology Male Mice Mice, Inbred BALB C Morus* Powders* Severity of Illness Index |
IF | 1.297 |
リソース情報 | |
一般微生物 | JCM11019 JCM1217 JCM1290 JCM1649 |