RRC ID 60289
著者 Wang Y, Hatabu T.
タイトル Mulberry juice freeze-dried powder attenuates the disease severity by the maintaining of colon mucosa in mice with DSS-induced acute colitis.
ジャーナル Biosci Biotechnol Biochem
Abstract This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions.
巻・号 83(5)
ページ 914-922
公開日 2019-5-1
DOI 10.1080/09168451.2019.1580135
PMID 30774006
MeSH Acute Disease Animals Beverages* Colitis / drug therapy* Colitis / physiopathology Dextran Sulfate / toxicity* Freeze Drying* Intestinal Mucosa / drug effects* Intestinal Mucosa / physiopathology Male Mice Mice, Inbred BALB C Morus* Powders* Severity of Illness Index
IF 1.297
リソース情報
一般微生物 JCM11019 JCM1217 JCM1290 JCM1649