Reference - Detail
| RRC ID | 60580 |
|---|---|
| Author | Wang RJ, Zhang SY, Ye YH, Yu Z, Qi H, Zhang H, Xue ZL, Wang JD, Wu M. |
| Title | Three New Isoflavonoid Glycosides from the Mangrove-Derived Actinomycete Micromonospora aurantiaca 110B. |
| Journal | Mar Drugs |
| Abstract |
The mangrove ecosystem is a rich resource for the discovery of actinomycetes with potential applications in pharmaceutical science. Besides the genus Streptomyces, Micromonospora is also a source of new bioactive agents. We screened Micromonospora from the rhizosphere soil of mangrove plants in Fujian province, China, and 51 strains were obtained. Among them, the extracts of 12 isolates inhibited the growth of human lung carcinoma A549 cells. Strain 110B exhibited better cytotoxic activity, and its bioactive constituents were investigated. Consequently, three new isoflavonoid glycosides, daidzein-4'-(2-deoxy-α-l-fucopyranoside) (1), daidzein-7-(2-deoxy-α-l-fucopyranoside) (2), and daidzein-4',7-di-(2-deoxy-α-l-fucopyranoside) (3) were isolated from the fermentation broth of strain 110B. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The result of medium-changing experiments implicated that these new compounds were microbial biotransformation products of strain M. aurantiaca 110B. The three compounds displayed moderate cytotoxic activity to the human lung carcinoma cell line A549, hepatocellular liver carcinoma cell line HepG2, and the human colon tumor cell line HCT116, whereas none of them showed antifungal or antibacterial activities. |
| Volume | 17(5) |
| Published | 2019-5-17 |
| DOI | 10.3390/md17050294 |
| PII | md17050294 |
| PMID | 31108876 |
| PMC | PMC6562861 |
| MeSH | A549 Cells Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Cell Survival / drug effects* Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology HCT116 Cells Hep G2 Cells Humans Isoflavones / chemistry Micromonospora / chemistry* Soil Microbiology |
| IF | 3.772 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM21373 |