論文 - 詳細
| RRC ID | 60617 |
|---|---|
| 著者 | Xiong L, Liu S, Chen S, Xiao Y, Zhu B, Gao Y, Zhang Y, Chen B, Luo J, Deng Z, Chen X, Wang L, Chen S. |
| タイトル | A new type of DNA phosphorothioation-based antiviral system in archaea. |
| ジャーナル | Nat Commun |
| Abstract |
Archaea and Bacteria have evolved different defence strategies that target virtually all steps of the viral life cycle. The diversified virion morphotypes and genome contents of archaeal viruses result in a highly complex array of archaea-virus interactions. However, our understanding of archaeal antiviral activities lags far behind our knowledges of those in bacteria. Here we report a new archaeal defence system that involves DndCDEA-specific DNA phosphorothioate (PT) modification and the PbeABCD-mediated halt of virus propagation via inhibition of DNA replication. In contrast to the breakage of invasive DNA by DndFGH in bacteria, DndCDEA-PbeABCD does not degrade or cleave viral DNA. The PbeABCD-mediated PT defence system is widespread and exhibits extensive interdomain and intradomain gene transfer events. Our results suggest that DndCDEA-PbeABCD is a new type of PT-based virus resistance system, expanding the known arsenal of defence systems as well as our understanding of host-virus interactions. |
| 巻・号 | 10(1) |
| ページ | 1688 |
| 公開日 | 2019-4-11 |
| DOI | 10.1038/s41467-019-09390-9 |
| PII | 10.1038/s41467-019-09390-9 |
| PMID | 30975999 |
| PMC | PMC6459918 |
| MeSH | Archaea / physiology* Archaea / virology Archaeal Proteins / genetics Archaeal Proteins / immunology Archaeal Proteins / metabolism* Archaeal Viruses / genetics* Archaeal Viruses / pathogenicity DNA Replication / immunology DNA, Viral / metabolism* Gene Transfer, Horizontal / immunology Host Microbial Interactions / genetics* Immunity, Innate / genetics Immunity, Innate / immunology Phosphorothioate Oligonucleotides / metabolism RNA, Archaeal / genetics RNA, Archaeal / isolation & purification Sequence Analysis, DNA |
| IF | 11.878 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM10635 JCM19729 JCM16811 |