| RRC ID |
60617
|
| 著者 |
Xiong L, Liu S, Chen S, Xiao Y, Zhu B, Gao Y, Zhang Y, Chen B, Luo J, Deng Z, Chen X, Wang L, Chen S.
|
| タイトル |
A new type of DNA phosphorothioation-based antiviral system in archaea.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Archaea and Bacteria have evolved different defence strategies that target virtually all steps of the viral life cycle. The diversified virion morphotypes and genome contents of archaeal viruses result in a highly complex array of archaea-virus interactions. However, our understanding of archaeal antiviral activities lags far behind our knowledges of those in bacteria. Here we report a new archaeal defence system that involves DndCDEA-specific DNA phosphorothioate (PT) modification and the PbeABCD-mediated halt of virus propagation via inhibition of DNA replication. In contrast to the breakage of invasive DNA by DndFGH in bacteria, DndCDEA-PbeABCD does not degrade or cleave viral DNA. The PbeABCD-mediated PT defence system is widespread and exhibits extensive interdomain and intradomain gene transfer events. Our results suggest that DndCDEA-PbeABCD is a new type of PT-based virus resistance system, expanding the known arsenal of defence systems as well as our understanding of host-virus interactions.
|
| 巻・号 |
10(1)
|
| ページ |
1688
|
| 公開日 |
2019-4-11
|
| DOI |
10.1038/s41467-019-09390-9
|
| PII |
10.1038/s41467-019-09390-9
|
| PMID |
30975999
|
| PMC |
PMC6459918
|
| MeSH |
Archaea / physiology*
Archaea / virology
Archaeal Proteins / genetics
Archaeal Proteins / immunology
Archaeal Proteins / metabolism*
Archaeal Viruses / genetics*
Archaeal Viruses / pathogenicity
DNA Replication / immunology
DNA, Viral / metabolism*
Gene Transfer, Horizontal / immunology
Host Microbial Interactions / genetics*
Immunity, Innate / genetics
Immunity, Innate / immunology
Phosphorothioate Oligonucleotides / metabolism
RNA, Archaeal / genetics
RNA, Archaeal / isolation & purification
Sequence Analysis, DNA
|
| IF |
11.878
|
| 引用数 |
10
|
| リソース情報 |
| 一般微生物 |
JCM10635
JCM19729
JCM16811 |
