論文 - 詳細
| RRC ID | 60625 |
|---|---|
| 著者 | Koyanagi Y, Suzuki R, Ihara K, Miyagi H, Isogai H, Yoneyama H, Isogai E. |
| タイトル | Intestinal Clostridium species lower host susceptibility to enterohemorrhagic Escherichia coli O157:H7 infection. |
| ジャーナル | Pathog Dis |
| Abstract |
Susceptibility to enterohemorrhagic Escherichia coli (EHEC) infection varies among humans. The intestinal microbiota seems to play an essential role in host defense against EHEC; thus, we hypothesized that indigenous bacteria, such as Clostridium ramosum and Clostridium perfringens, could influence the susceptibility to EHEC infection. To evaluate the effect of indigenous bacteria on EHEC infection, germ-free mice were precolonized with each indigenous bacterium, and then infected with EHEC O157:H7. Precolonization with C. ramosum or C. perfringens completely prevented death from EHEC infection througout a test period. Precolonization with C. ramosum also reduced the level of secreted Shiga toxin (Stx) 2 and prevented histopathological changes in the kidneys in a similar way to precolonization with Bifidobacterium longum, which is used as a model for preventing EHEC infection. In contrast, the mice precolonized with C. perfringens showed mild renal injuries. When evaluated using an in vitro co-culturing system, again C. ramosum inhibited the growth and Stx production of EHEC more potently than C. perfringens. These results indicate that C. ramosum and C. perfringens suppressed EHEC infection; however, the extent of their preventive effects differed. Therefore, the susceptibility to EHEC infection and its severity can depend on the functional bacteria present in the intestinal microbiota of individuals. |
| 巻・号 | 77(4) |
| 公開日 | 2019-6-1 |
| DOI | 10.1093/femspd/ftz036 |
| PII | 5538763 |
| PMID | 31344225 |
| MeSH | Animals Antibiosis* Clostridium perfringens / growth & development* Disease Models, Animal Disease Susceptibility* Escherichia coli Infections / microbiology Escherichia coli Infections / pathology Escherichia coli Infections / prevention & control* Escherichia coli O157 / growth & development* Firmicutes / growth & development* Gastrointestinal Microbiome Mice |
| IF | 2.166 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM1217 JCM1290 JCM1298 |