| RRC ID |
60640
|
| 著者 |
Law JW, Ser HL, Ab Mutalib NS, Saokaew S, Duangjai A, Khan TM, Chan KG, Goh BH, Lee LH.
|
| タイトル |
Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential.
|
| ジャーナル |
Sci Rep
|
| Abstract |
A new Streptomyces species discovered from Sarawak mangrove soil is described, with the proposed name - Streptomyces monashensis sp. nov. (strain MUSC 1JT). Taxonomy status of MUSC 1JT was determined via polyphasic approach. Phylogenetic and chemotaxonomic properties of strain MUSC 1JT were in accordance with those known for genus Streptomyces. Based on phylogenetic analyses, the strains closely related to MUSC 1JT were Streptomyces corchorusii DSM 40340T (98.7%), Streptomyces olivaceoviridis NBRC 13066T (98.7%), Streptomyces canarius NBRC 13431T (98.6%) and Streptomyces coacervatus AS-0823T (98.4%). Outcomes of DNA-DNA relatedness between strain MUSC 1JT and its closely related type strains covered from 19.7 ± 2.8% to 49.1 ± 4.3%. Strain MUSC 1JT has genome size of 10,254,857 bp with DNA G + C content of 71 mol%. MUSC 1JT extract exhibited strong antioxidative activity up to 83.80 ± 4.80% in the SOD assay, with significant cytotoxic effect against colon cancer cell lines HCT-116 and SW480. Streptomyces monashensis MUSC 1JT (=DSM 103626T = MCCC 1K03221T) could potentially be a producer of novel bioactive metabolites; hence discovery of this new species may be highly significant to the biopharmaceutical industry as it could lead to development of new and useful chemo-preventive drugs.
|
| 巻・号 |
9(1)
|
| ページ |
3056
|
| 公開日 |
2019-2-28
|
| DOI |
10.1038/s41598-019-39592-6
|
| PII |
10.1038/s41598-019-39592-6
|
| PMID |
30816228
|
| PMC |
PMC6395624
|
| MeSH |
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / metabolism
Antineoplastic Agents / pharmacology*
Antioxidants / isolation & purification
Antioxidants / metabolism
Antioxidants / pharmacology*
Bacterial Typing Techniques
Base Composition
Cell Survival / drug effects
DNA, Bacterial / isolation & purification
HCT116 Cells
Humans
Malaysia
Phylogeny
RNA, Ribosomal, 16S / genetics
Sequence Analysis, DNA
Soil Microbiology*
Streptomyces / genetics
Streptomyces / isolation & purification
Streptomyces / metabolism*
Superoxides / antagonists & inhibitors
|
| IF |
4.011
|
| 引用数 |
8
|
| リソース情報 |
| 一般微生物 |
JCM4467
JCM4499
JCM4549
JCM17318 |
