RRC ID 60792
著者 Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, Okazawa H.
タイトル Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship.
ジャーナル FEBS Lett
Abstract Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting intelligence, we generated transgenic flies expressing human PQBP-1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long-term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP-1 or its binding partner might be linked to these symptoms.
巻・号 580(9)
ページ 2335-40
公開日 2006-4-17
DOI 10.1016/j.febslet.2006.03.056
PII S0014-5793(06)00371-1
PMID 16597440
MeSH Animals Animals, Genetically Modified Behavior, Animal* Carrier Proteins / genetics* DNA-Binding Proteins Disease Models, Animal Drosophila melanogaster Frameshift Mutation* Humans Intellectual Disability / genetics* Male Memory* Nuclear Proteins / genetics* Protein Structure, Tertiary / genetics
IF 3.057
引用数 15
リソース情報
ショウジョウバエ