論文 - 詳細
| RRC ID | 60792 |
|---|---|
| 著者 | Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, Okazawa H. |
| タイトル | Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship. |
| ジャーナル | FEBS Lett |
| Abstract |
Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting intelligence, we generated transgenic flies expressing human PQBP-1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long-term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP-1 or its binding partner might be linked to these symptoms. |
| 巻・号 | 580(9) |
| ページ | 2335-40 |
| 公開日 | 2006-4-17 |
| DOI | 10.1016/j.febslet.2006.03.056 |
| PII | S0014-5793(06)00371-1 |
| PMID | 16597440 |
| MeSH | Animals Animals, Genetically Modified Behavior, Animal* Carrier Proteins / genetics* DNA-Binding Proteins Disease Models, Animal Drosophila melanogaster Frameshift Mutation* Humans Intellectual Disability / genetics* Male Memory* Nuclear Proteins / genetics* Protein Structure, Tertiary / genetics |
| IF | 3.057 |
| 引用数 | 15 |
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