論文 - 詳細
| RRC ID | 60803 |
|---|---|
| 著者 | Jurišić Dukovski B, Juretić M, Bračko D, Randjelović D, Savić S, Crespo Moral M, Diebold Y, Filipović-Grčić J, Pepić I, Lovrić J. |
| タイトル | Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment. |
| ジャーナル | Int J Pharm |
| Abstract |
Inflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation issues. The aim of this study was development and optimization of functional cationic nanoemulsions (NEs) for DED treatment, as a formulation approach to circumvent solubility problems, prolong drug residence at the ocular surface and stabilize the tear film. Ibuprofen was employed as the model NSAID, chitosan as the cationic agent, and lecithin as the anionic surfactant enabling chitosan incorporation. Moreover, lecithin is a mixture of phospholipids including phosphatidylcholine and phosphatidylethanolamine, two constituents of the natural tear film important for its stability. NEs were characterized in terms of droplet size, polydispersity index, zeta-potential, pH, viscosity, osmolarity, surface tension, entrapment efficiency, stability, sterilizability and in vitro release. NEs mucoadhesive properties were tested rheologically after mixing with mucin dispersion. Biocompatibility was assessed employing 3D HCE-T cell-based model and ex vivo model using porcine corneas. The results of our study pointed out the NE formulation with 0.05% (w/w) chitosan as the lead formulation with physicochemical properties adequate for ophthalmic application, mucoadhesive character and excellent biocompatibility. |
| 巻・号 | 576 |
| ページ | 118979 |
| 公開日 | 2020-2-25 |
| DOI | 10.1016/j.ijpharm.2019.118979 |
| PII | S0378-5173(19)31039-7 |
| PMID | 31870964 |
| MeSH | Animals Cations / chemistry* Cell Line Chemistry, Pharmaceutical / methods Chitosan / chemistry Drug Delivery Systems / methods Drug Stability Dry Eye Syndromes / drug therapy* Emulsions / chemistry* Emulsions / pharmacology* Female Humans Ibuprofen / chemistry* Ibuprofen / pharmacology* Lecithins / chemistry Male Nanoparticles / chemistry* Particle Size Solubility Surface-Active Agents / chemistry Swine Viscosity |
| IF | 4.213 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HCE-T(RCB2280) |