論文 - 詳細
| RRC ID | 60810 |
|---|---|
| 著者 | Khadilkar RJ, Ho KYL, Venkatesh B, Tanentzapf G. |
| タイトル | Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis. |
| ジャーナル | Curr Biol |
| Abstract |
During hematopoiesis, progenitor cells receive and interpret a diverse array of regulatory signals from their environment. These signals control the maintenance of the progenitors and regulate the production of mature blood cells. Integrins are well known in vertebrates for their roles in hematopoiesis, particularly in assisting in the migration to, as well as the physical attachment of, progenitors to the niche. However, whether and how integrins are also involved in the signaling mechanisms that control hematopoiesis remains to be resolved. Here, we show that integrins play a key role during fly hematopoiesis in regulating cell signals that control the behavior of hematopoietic progenitors. Integrins can regulate hematopoiesis directly, via focal adhesion kinase (FAK) signaling, and indirectly, by directing extracellular matrix (ECM) assembly and/or maintenance. ECM organization and density controls blood progenitor behavior by modulating multiple signaling pathways, including bone morphogenetic protein (BMP) and Hedgehog (Hh). Furthermore, we show that integrins and the ECM are reduced following infection, which may assist in activating the immune response. Our results provide mechanistic insight into how integrins can shape the signaling environment around hematopoietic progenitors. |
| 巻・号 | 30(17) |
| ページ | 3316-3329.e5 |
| 公開日 | 2020-9-7 |
| DOI | 10.1016/j.cub.2020.06.027 |
| PII | S0960-9822(20)30843-5 |
| PMID | 32649911 |
| MeSH | Animals Blood Cells / immunology* Blood Cells / metabolism Blood Cells / parasitology Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / immunology* Drosophila melanogaster / metabolism Drosophila melanogaster / parasitology Extracellular Matrix / physiology* Hedgehog Proteins / genetics Hedgehog Proteins / metabolism Hematopoiesis* Integrins / genetics Integrins / metabolism* Signal Transduction Wasps / physiology |
| IF | 9.193 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 129 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 1560R-1 |