| RRC ID |
60817
|
| 著者 |
Dufour HD, Koshikawa S, Finet C.
|
| タイトル |
Temporal flexibility of gene regulatory network underlies a novel wing pattern in flies.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
Organisms have evolved endless morphological, physiological, and behavioral novel traits during the course of evolution. Novel traits were proposed to evolve mainly by orchestration of preexisting genes. Over the past two decades, biologists have shown that cooption of gene regulatory networks (GRNs) indeed underlies numerous evolutionary novelties. However, very little is known about the actual GRN properties that allow such redeployment. Here we have investigated the generation and evolution of the complex wing pattern of the fly Samoaia leonensis We show that the transcription factor Engrailed is recruited independently from the other players of the anterior-posterior specification network to generate a new wing pattern. We argue that partial cooption is made possible because 1) the anterior-posterior specification GRN is flexible over time in the developing wing and 2) this flexibility results from the fact that every single gene of the GRN possesses its own functional time window. We propose that the temporal flexibility of a GRN is a general prerequisite for its possible cooption during the course of evolution.
|
| 巻・号 |
117(21)
|
| ページ |
11589-11596
|
| 公開日 |
2020-5-26
|
| DOI |
10.1073/pnas.2002092117
|
| PII |
2002092117
|
| PMID |
32393634
|
| PMC |
PMC7261121
|
| MeSH |
Animals
Body Patterning / genetics
Drosophilidae* / genetics
Drosophilidae* / growth & development
Gene Expression Regulation, Developmental / genetics*
Gene Regulatory Networks / genetics*
Insect Proteins / genetics
Pigmentation / genetics*
Transcription Factors / genetics
Wings, Animal* / anatomy & histology
Wings, Animal* / growth & development
Wings, Animal* / physiology
|
| IF |
9.58
|
| 引用数 |
0
|
| リソース情報 |
| ショウジョウバエ |
S. leonensis |
