論文 - 詳細
| RRC ID | 60829 |
|---|---|
| 著者 | Chikada H, Ida K, Nishikawa Y, Inagaki Y, Kamiya A. |
| タイトル | Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice. |
| ジャーナル | Sci Rep |
| Abstract |
The prevalence of non-alcoholic steatohepatitis (NASH) rapidly increases with metabolic disorders such as dyslipidaemia, high blood pressure, and hyperglycaemia. B cell lymphoma 6 (Bcl6), a transcriptional repressor, is essential for the formation of germinal centre B cells. In this study, we analysed the role of Bcl6 in NASH progression-associated pathological changes, such as hepatic lipid accumulation, liver fibrosis, and hepatocarcinogenesis. The roles of Bcl6 in NASH were analysed using liver-specific Bcl6 knockout (Bcl6-LKO) and control wild-type (WT) mice. The murine NASH model was established by feeding the mice with choline-deficient, L-amino-acid-defined, high-fat diet (CDAHFD). Feeding the WT mice with CDAHFD for 7 weeks induced the formation of histopathological features resembling human NASH, such as hepatic lipid accumulation, hepatocellular injury, and fibrosis. These histopathological changes were significantly attenuated in Bcl6-LKO mice. Additionally, feeding the male WT mice with CDAHFD for 38 weeks induced the formation of liver tumours, which was suppressed in Bcl6-LKO mice. These findings indicate that Bcl6 is involved in the progression of NASH and NASH-derived tumours. |
| 巻・号 | 10(1) |
| ページ | 9704 |
| 公開日 | 2020-6-16 |
| DOI | 10.1038/s41598-020-66539-z |
| PII | 10.1038/s41598-020-66539-z |
| PMID | 32546802 |
| PMC | PMC7297717 |
| MeSH | Animals Disease Models, Animal Disease Progression Female Lipid Metabolism Liver / chemistry Liver / metabolism* Male Mice Mice, Knockout Non-alcoholic Fatty Liver Disease / etiology Non-alcoholic Fatty Liver Disease / metabolism Non-alcoholic Fatty Liver Disease / pathology* Proto-Oncogene Proteins c-bcl-6 / metabolism* Proto-Oncogene Proteins c-bcl-6 / physiology Real-Time Polymerase Chain Reaction Triglycerides / analysis Triglycerides / metabolism |
| IF | 4.011 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC05663 |