RRC ID 60861
著者 Mabuchi S, Komura N, Sasano T, Shimura K, Yokoi E, Kozasa K, Kuroda H, Takahashi R, Kawano M, Matsumoto Y, Kato H, Hatazawa J, Kimura T.
タイトル Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies.
ジャーナル Nat Commun
Abstract The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we investigate the impact of pretreatment tumor-related leukocytosis (TRL) on the diagnostic performance of 18F-FDG-PET/CT in detecting pelvic and paraaortic lymph node metastasis. We demonstrate that pretreatment TRL misleads 18F-FDG-PET/CT during lymph node staging in gynecological malignancies. In the mechanistic investigations, we show that the false-positive 18F-FDG-PET/CT result for detecting nodal metastasis can be reproduced in animal models of TRL-positive cancer bearing G-CSF expressing cervical cancer cells. We also show that increased 18F-FDG uptake in non-metastatic nodes can be explained by the MDSC-mediated premetastatic niche formation in which proinflammatory factors, such as S100A8 or S100A9, are abundantly expressed. Together, our results suggest that the MDSC-mediated premetastatic niche created in the lymph node of TRL-positive patients misleads 18F-FDG-PET/CT for detecting nodal metastasis.
巻・号 11(1)
ページ 1364
公開日 2020-3-13
DOI 10.1038/s41467-020-15186-z
PII 10.1038/s41467-020-15186-z
PMID 32170086
PMC PMC7069975
MeSH Animals Cell Line, Tumor Disease Models, Animal Female Fluorodeoxyglucose F18 Humans Leukocytosis / diagnostic imaging Leukocytosis / pathology* Lymph Nodes / diagnostic imaging Lymph Nodes / pathology* Middle Aged Neoplasms / diagnostic imaging Neoplasms / pathology* Positron Emission Tomography Computed Tomography / methods* Uterine Cervical Neoplasms / diagnostic imaging Uterine Cervical Neoplasms / pathology
IF 11.878
リソース情報
遺伝子材料 pCAmGCSF (RDB01522) pCAZ 2 (RDB01870)