| RRC ID |
61036
|
| Author |
Harada N, Minami Y, Hanada K, Hanaoka R, Kobayashi Y, Izawa T, Sato T, Kato S, Inui H, Yamaji R.
|
| Title |
Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders.
|
| Journal |
Gut Microbes
|
| Abstract |
Androgen action generates sex-related differences that include changes in the gut microbiota composition. Hypoandrogenism and hyperandrogenism in males and females, respectively, are associated with the prevalence of metabolic disorders. Our recent work showed that male androgen receptor knockout (ARKO) mice developed high-fat diet (HFD)-dependent sarcopenic abdominal obesity, hyperglycemia, and hepatic steatosis, leading to early death. The ARKO mice also exhibited alterations in intestinal microbiota but did not experience metabolic abnormalities when administered with antibiotics. Here, we show that time-dependent changes in feed efficiency (ratio of body weight gain to food intake) and weight of dried feces-to-food ratio could be good markers for changes in gut microbiota. Turicibacter spp., Lactobacillus spp., and L. reuteri increased in the gut in both HFD-fed ARKO and castrated mice having metabolic abnormalities. HFD-fed ARKO mice showed increased plasma levels of aspartate, but not alanine, aminotransferase. Changes in the gut microbiome appear to provoke androgen deficiency-induced metabolic diseases, leading to early mortality.
|
| Volume |
12(1)
|
| Pages |
1817719
|
| Published |
2020-11-9
|
| DOI |
10.1080/19490976.2020.1817719
|
| PMID |
32991827
|
| PMC |
PMC7781658
|
| MeSH |
Androgens / deficiency*
Animals
Eating
Feces / chemistry
Feces / microbiology*
Gastrointestinal Microbiome*
Humans
Metabolic Diseases / etiology*
Metabolic Diseases / genetics
Metabolic Diseases / metabolism*
Metabolic Diseases / microbiology
Receptors, Androgen / genetics
Receptors, Androgen / metabolism
|
| IF |
7.74
|
| Resource |
| Mice |
RBRC01828 |
