RRC ID 61036
Author Harada N, Minami Y, Hanada K, Hanaoka R, Kobayashi Y, Izawa T, Sato T, Kato S, Inui H, Yamaji R.
Title Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders.
Journal Gut Microbes
Abstract Androgen action generates sex-related differences that include changes in the gut microbiota composition. Hypoandrogenism and hyperandrogenism in males and females, respectively, are associated with the prevalence of metabolic disorders. Our recent work showed that male androgen receptor knockout (ARKO) mice developed high-fat diet (HFD)-dependent sarcopenic abdominal obesity, hyperglycemia, and hepatic steatosis, leading to early death. The ARKO mice also exhibited alterations in intestinal microbiota but did not experience metabolic abnormalities when administered with antibiotics. Here, we show that time-dependent changes in feed efficiency (ratio of body weight gain to food intake) and weight of dried feces-to-food ratio could be good markers for changes in gut microbiota. Turicibacter spp., Lactobacillus spp., and L. reuteri increased in the gut in both HFD-fed ARKO and castrated mice having metabolic abnormalities. HFD-fed ARKO mice showed increased plasma levels of aspartate, but not alanine, aminotransferase. Changes in the gut microbiome appear to provoke androgen deficiency-induced metabolic diseases, leading to early mortality.
Volume 12(1)
Pages 1817719
Published 2020-11-9
DOI 10.1080/19490976.2020.1817719
PMID 32991827
PMC PMC7781658
MeSH Androgens / deficiency* Animals Eating Feces / chemistry Feces / microbiology* Gastrointestinal Microbiome* Humans Metabolic Diseases / etiology* Metabolic Diseases / genetics Metabolic Diseases / metabolism* Metabolic Diseases / microbiology Receptors, Androgen / genetics Receptors, Androgen / metabolism
IF 7.74
Mice RBRC01828