論文 - 詳細
| RRC ID | 61106 |
|---|---|
| 著者 | Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Oda T, Konishi H, Yamawaki M, Itoh Y, Nakaya T. |
| タイトル | Long-term detection of seasonal influenza RNA in faeces and intestine. |
| ジャーナル | Clin Microbiol Infect |
| Abstract |
Some cases of seasonal influenza virus (human influenza A virus (IAV)/human influenza B virus (IBV)) are associated with abdominal symptoms. Although virus RNA has been detected in faeces, intestinal infection has not been clearly demonstrated. We aimed to provide evidence that IAV/IBV infects the human intestine. This prospective observational study measured virus RNA in faecal and sputum samples from 22 patients infected with IAV/IBV (19 IAV positive and three IBV positive). Nineteen patients were included in the analysis and were assigned to faecal IAV-positive and -negative groups. Virus kinetics were examined in faecal samples from an IAV-infected patient (patient 1) and an IBV-infected patient (patient 2). Finally, intestinal tissue from an IAV-diagnosed patient who developed haemorrhagic colitis and underwent colonoscopy was examined for the presence of replicating IAV (patient 3). Virus RNA was detected in faecal samples from 8/22 IAV/IBV-infected patients (36.4%). Diarrhoea occurred significantly more often in the faecal IAV-positive group (p 0.002). In patients 1 and 2, virus RNA became undetectable in sputum on days 7 and 10 after infection, respectively, but was detected in faeces for a further 2 weeks. Virus mRNA and antigens were detected in intestinal tissues (mucosal epithelium of the sigmoid colon) from patient 3. These findings suggest that IAV/IBV infects within the intestinal tract; thus, the human intestine may be an additional target organ for IAV/IBV infection. |
| 巻・号 | 22(9) |
| ページ | 813.e1-813.e7 |
| 公開日 | 2016-9-1 |
| DOI | 10.1016/j.cmi.2016.06.015 |
| PII | S1198-743X(16)30215-4 |
| PMID | 27424942 |
| MeSH | Adolescent Adult Aged Animals Biopsy Cell Line Child Child, Preschool Colonoscopes Feces / virology* Female Humans Infant Influenza A virus / genetics Influenza, Human / diagnosis Influenza, Human / epidemiology* Influenza, Human / virology* Influenzavirus B / genetics Intestines / pathology Intestines / virology* Male Middle Aged Prospective Studies RNA, Viral* Seasons* Viral Load Young Adult |
| IF | 7.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 30 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MDCK(RCB0995) |