RRC ID |
61106
|
著者 |
Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Oda T, Konishi H, Yamawaki M, Itoh Y, Nakaya T.
|
タイトル |
Long-term detection of seasonal influenza RNA in faeces and intestine.
|
ジャーナル |
Clin Microbiol Infect
|
Abstract |
Some cases of seasonal influenza virus (human influenza A virus (IAV)/human influenza B virus (IBV)) are associated with abdominal symptoms. Although virus RNA has been detected in faeces, intestinal infection has not been clearly demonstrated. We aimed to provide evidence that IAV/IBV infects the human intestine. This prospective observational study measured virus RNA in faecal and sputum samples from 22 patients infected with IAV/IBV (19 IAV positive and three IBV positive). Nineteen patients were included in the analysis and were assigned to faecal IAV-positive and -negative groups. Virus kinetics were examined in faecal samples from an IAV-infected patient (patient 1) and an IBV-infected patient (patient 2). Finally, intestinal tissue from an IAV-diagnosed patient who developed haemorrhagic colitis and underwent colonoscopy was examined for the presence of replicating IAV (patient 3). Virus RNA was detected in faecal samples from 8/22 IAV/IBV-infected patients (36.4%). Diarrhoea occurred significantly more often in the faecal IAV-positive group (p 0.002). In patients 1 and 2, virus RNA became undetectable in sputum on days 7 and 10 after infection, respectively, but was detected in faeces for a further 2 weeks. Virus mRNA and antigens were detected in intestinal tissues (mucosal epithelium of the sigmoid colon) from patient 3. These findings suggest that IAV/IBV infects within the intestinal tract; thus, the human intestine may be an additional target organ for IAV/IBV infection.
|
巻・号 |
22(9)
|
ページ |
813.e1-813.e7
|
公開日 |
2016-9-1
|
DOI |
10.1016/j.cmi.2016.06.015
|
PII |
S1198-743X(16)30215-4
|
PMID |
27424942
|
MeSH |
Adolescent
Adult
Aged
Animals
Biopsy
Cell Line
Child
Child, Preschool
Colonoscopes
Feces / virology*
Female
Humans
Infant
Influenza A virus / genetics
Influenza, Human / diagnosis
Influenza, Human / epidemiology*
Influenza, Human / virology*
Influenzavirus B / genetics
Intestines / pathology
Intestines / virology*
Male
Middle Aged
Prospective Studies
RNA, Viral*
Seasons*
Viral Load
Young Adult
|
IF |
7.117
|
リソース情報 |
ヒト・動物細胞 |
MDCK(RCB0995) |