RRC ID 61110
Author Nakata T, Kitamura Y, Shimizu K, Tanaka S, Fujimori M, Yokoyama S, Ito K, Emi M.
Title Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.
Journal Genes Chromosomes Cancer
Abstract In papillary thyroid carcinomas, the genes for receptor-type tyrosine kinase, RET or TRKA, are sometimes rearranged, resulting in fusion of its tyrosine kinase domain to 5' portions of several activating genes. In a papillary thyroid carcinoma, we identified a novel gene (ELKS), the 5' portion of which is fused to the RET gene by gene rearrangement due to the translocation t(10;12)(q11;p13). Subsequent cloning of the ELKS cDNA revealed that ELKS encodes a novel 948 amino acid peptide and is expressed ubiquitously in human tissues. The presence of multiple coiled-coil domains in the ELKS product suggests that the ELKS protein forms dimers. Since the tyrosine kinase of RET is activated by dimerization that occurs when its ligands bind to the receptor, fusion of RET with the 5' dimerization domains of ELKS would activate its cytoplasmic tyrosine kinase constitutively in papillary thyroid carcinomas.
Volume 25(2)
Pages 97-103
Published 1999-6-1
DOI 10.1002/(sici)1098-2264(199906)25:2<97::aid-gcc4>3.0.co;2-l
PII 10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L
PMID 10337992
MeSH Amino Acid Sequence Carcinoma, Papillary / genetics* Chromosome Mapping Chromosomes, Human, Pair 10 / genetics* Chromosomes, Human, Pair 12 / genetics* Cloning, Molecular DNA, Neoplasm / analysis Dimerization Drosophila Proteins* Humans Molecular Sequence Data Protein Structure, Secondary Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases / genetics* Recombinant Fusion Proteins / biosynthesis Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / physiology Sequence Analysis, DNA Thyroid Neoplasms / genetics* Translocation, Genetic / genetics*
IF 2.94
Resource
DNA material human ELKS alpha (RDB18198)