| RRC ID |
61110
|
| 著者 |
Nakata T, Kitamura Y, Shimizu K, Tanaka S, Fujimori M, Yokoyama S, Ito K, Emi M.
|
| タイトル |
Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.
|
| ジャーナル |
Genes Chromosomes Cancer
|
| Abstract |
In papillary thyroid carcinomas, the genes for receptor-type tyrosine kinase, RET or TRKA, are sometimes rearranged, resulting in fusion of its tyrosine kinase domain to 5' portions of several activating genes. In a papillary thyroid carcinoma, we identified a novel gene (ELKS), the 5' portion of which is fused to the RET gene by gene rearrangement due to the translocation t(10;12)(q11;p13). Subsequent cloning of the ELKS cDNA revealed that ELKS encodes a novel 948 amino acid peptide and is expressed ubiquitously in human tissues. The presence of multiple coiled-coil domains in the ELKS product suggests that the ELKS protein forms dimers. Since the tyrosine kinase of RET is activated by dimerization that occurs when its ligands bind to the receptor, fusion of RET with the 5' dimerization domains of ELKS would activate its cytoplasmic tyrosine kinase constitutively in papillary thyroid carcinomas.
|
| 巻・号 |
25(2)
|
| ページ |
97-103
|
| 公開日 |
1999-6-1
|
| DOI |
10.1002/(sici)1098-2264(199906)25:2<97::aid-gcc4>3.0.co;2-l
|
| PII |
10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L
|
| PMID |
10337992
|
| MeSH |
Amino Acid Sequence
Carcinoma, Papillary / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 10 / genetics*
Chromosomes, Human, Pair 12 / genetics*
Cloning, Molecular
DNA, Neoplasm / analysis
Dimerization
Drosophila Proteins*
Humans
Molecular Sequence Data
Protein Structure, Secondary
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases / genetics*
Recombinant Fusion Proteins / biosynthesis
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / physiology
Sequence Analysis, DNA
Thyroid Neoplasms / genetics*
Translocation, Genetic / genetics*
|
| IF |
3.444
|
| リソース情報 |
| 遺伝子材料 |
human ELKS alpha (RDB18198) |
