Reference - Detail
| RRC ID | 61118 |
|---|---|
| Author | Asayama S, Sakata M, Kawakami H. |
| Title | Structure-activity relationship between Zn2+-chelated alkylated poly(1-vinylimidazole) and gene transfection. |
| Journal | J Inorg Biochem |
| Abstract |
The structure-activity relationship between Zn2+-chelated alkylated poly(1-vinylimidazole) (PVIm) and gene transfection has been demonstrated. From a chemical structure perspective, ethylated PVIm (PVIm-Et) chelated the most Zn2+ ions compared to methylated PVIm (PVIm-Me) and butylated PVIm (PVIm-Bu). The resulting Zn2+-chelated PVIm-Et formed more stable complexes with plasmid DNA complex than non-chelated PVIm-Et. From a biological activity perspective, the Zn2+-chelated PVIm-Et delivered the highest amount of Zn2+ ions inside the cell, corresponding to the highest gene transfection. These results suggest that PVIm-Et is the optimal sequence for the chelation of Zn2+ ions to enhance the gene transfection activity. The structure-activity relationship in this study is expected to offer a unique molecular design for drug/gene delivery systems. |
| Volume | 173 |
| Pages | 120-125 |
| Published | 2017-8-1 |
| DOI | 10.1016/j.jinorgbio.2017.05.007 |
| PII | S0162-0134(16)30424-X |
| PMID | 28511062 |
| MeSH | Alkylating Agents / chemistry* Chelating Agents / chemistry* Imidazoles / chemistry* Polyvinyls / chemistry* Structure-Activity Relationship Transfection Zinc / chemistry* |
| IF | 3.212 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Hep G2(RCB1648) |