論文 - 詳細
| RRC ID | 61131 |
|---|---|
| 著者 | Feng C, She J, Chen X, Zhang Q, Zhang X, Wang Y, Ye J, Shi J, Tao J, Feng M, Guan W, Xia H, Zhang W, Xu G. |
| タイトル | Exosomal miR-196a-1 promotes gastric cancer cell invasion and metastasis by targeting SFRP1. |
| ジャーナル | Nanomedicine (Lond) |
| Abstract |
Aim: To investigate the role of exosomal miRNAs on gastric cancer (GC) metastasis. Materials & methods: miRNA expression profiles of exosomes with distinct invasion potentials were analyzed using miRNA microarray and validated by quantitative real-time PCR. In vitro and in vivo experiments assessed the role of exosomal miR-196a-1 in GC's metastasis. Results: High expression level of exosomal miR-196a-1 expression was significantly associated with poor survival in GC. Exosomes that contained miR-196a-1 were secreted from high-invasive GC cells. Ectopic miR-196a-1 expression promoted invasion of low-invasive GC cells by targeting SFRP1. Conclusion: miR-196a-1 was delivered from high-invasive GC into low-invasive GC cells via exosomes and promoted metastasis to the liver in vitro and in vivo. |
| 巻・号 | 14(19) |
| ページ | 2579-2593 |
| 公開日 | 2019-10-1 |
| DOI | 10.2217/nnm-2019-0053 |
| PMID | 31609675 |
| MeSH | Animals Cell Line, Tumor Cell Proliferation / genetics Coculture Techniques Exosomes / genetics Gene Expression Regulation, Neoplastic / genetics Heterografts Humans Intercellular Signaling Peptides and Proteins / genetics* Membrane Proteins / genetics* Mice MicroRNAs / genetics* Neoplasm Invasiveness / genetics* Neoplasm Invasiveness / pathology Neoplasm Metastasis Stomach Neoplasms / genetics* Stomach Neoplasms / pathology |
| IF | 4.3 |
| リソース情報 | |
| ヒト・動物細胞 | GSU(RCB2278) |