| RRC ID |
61154
|
| 著者 |
Liu SQ, Kawai K, Shiraiwa H, Hayashi H, Akaza H, Hashizaki K, Shiba R, Saijo K, Ohno T.
|
| タイトル |
High rate of induction of human autologous cytotoxic T lymphocytes against renal carcinoma cells cultured with an interleukin cocktail.
|
| ジャーナル |
Jpn J Cancer Res
|
| Abstract |
A high rate of induction (9 of 10 cases) of human autologous cytotoxic T lymphocytes (CTL) was achieved in vitro from peripheral blood mononuclear cells of renal carcinoma patients by applying an interleukin (IL)-cocktail consisting of IL-1, -2, -4, and -6. The CTL specifically lysed their own target carcinoma cells within 24 h but did not kill neighboring autologous normal kidney cells or allogeneic renal cancer cell lines. In the case of TUHR4TKB, for which autologous CTL were not induced, no expression of MHC class-I molecules was observed on the surface of these carcinoma cells, although they were sensitive to autologous natural killer cells. The results imply that adoptive immunotherapy for metastasized renal carcinoma will be feasible with autologous CTL in combination with natural killer cells.
|
| 巻・号 |
89(11)
|
| ページ |
1195-201
|
| 公開日 |
1998-11-1
|
| DOI |
10.1111/j.1349-7006.1998.tb00515.x
|
| PII |
S0910505099800155
|
| PMID |
9914789
|
| PMC |
PMC5921718
|
| MeSH |
Cell Survival
Humans
Interleukins / therapeutic use*
Kidney Neoplasms / drug therapy*
Kidney Neoplasms / immunology
Kidney Neoplasms / pathology
Killer Cells, Natural / immunology
Recombinant Proteins / therapeutic use
Reproducibility of Results
T-Lymphocytes, Cytotoxic / drug effects*
T-Lymphocytes, Cytotoxic / transplantation
Transplantation, Autologous
Tumor Cells, Cultured
|
| リソース情報 |
| ヒト・動物細胞 |
DAUDI(RCB1640)
K562(RCB0027)
OS-RC-2(RCB0735) |
