論文 - 詳細
| RRC ID | 61159 |
|---|---|
| 著者 | Hino N, Rossetti L, Marín-Llauradó A, Aoki K, Trepat X, Matsuda M, Hirashima T. |
| タイトル | ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. |
| ジャーナル | Dev Cell |
| Abstract |
During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission is coordinated with intracellular biochemical signaling to achieve collective movements. Here, we show that intercellular coupling of extracellular signal-regulated kinase (ERK)-mediated mechanochemical feedback yields long-distance transmission of guidance cues. Mechanical stretch activates ERK through epidermal growth factor receptor (EGFR) activation, and ERK activation triggers cell contraction. The contraction of the activated cell pulls neighboring cells, evoking another round of ERK activation and contraction in the neighbors. Furthermore, anisotropic contraction based on front-rear polarization guarantees unidirectional propagation of ERK activation, and in turn, the ERK activation waves direct multicellular alignment of the polarity, leading to long-range ordered migration. Our findings reveal that mechanical forces mediate intercellular signaling underlying sustained transmission of guidance cues for collective cell migration. |
| 巻・号 | 53(6) |
| ページ | 646-660.e8 |
| 公開日 | 2020-6-22 |
| DOI | 10.1016/j.devcel.2020.05.011 |
| PII | S1534-5807(20)30400-7 |
| PMID | 32497487 |
| MeSH | Animals Cell Movement* Cell Polarity* Dogs ErbB Receptors / metabolism MAP Kinase Signaling System* Madin Darby Canine Kidney Cells Mechanotransduction, Cellular* |
| IF | 10.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 206 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MDCK(RCB0995) |
| 遺伝子材料 | pCMV-VSV-G-RSV-Rev (RDB04393) |