Reference - Detail
| RRC ID | 61178 |
|---|---|
| Author | Warashina T, Umehara K, Miyase T, Noro T. |
| Title | 8,12;8,20-diepoxy-8,14-secopregnane glycosides from roots of Asclepias tuberosa and their effect on proliferation of human skin fibroblasts. |
| Journal | Phytochemistry |
| Abstract |
A pregnane glycoside fraction from the roots of Asclepias tuberosa L. caused normal human skin fibroblasts to proliferate. This fraction contained 21 pregnane glycosides whose structures were established using NMR spectroscopic analysis and chemical evidence. The aglycones of most of these compounds were identified as 8,12;8,20-diepoxy-8,14-secopregnanes, such as tuberogenin or 5,6-didehydrotuberogenin, the same aglycones as constituents of the aerial parts of this plant. Some of these compounds also caused proliferation of skin fibroblasts. |
| Volume | 72(14-15) |
| Pages | 1865-75 |
| Published | 2011-10-1 |
| DOI | 10.1016/j.phytochem.2011.05.012 |
| PII | S0031-9422(11)00277-9 |
| PMID | 21703653 |
| MeSH | Asclepias / chemistry* Cell Proliferation / drug effects Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology* Humans Magnetic Resonance Spectroscopy Molecular Structure Plant Components, Aerial / chemistry Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Roots / chemistry Pregnanes / chemistry Pregnanes / isolation & purification Pregnanes / pharmacology* Saponins / chemistry Saponins / isolation & purification Saponins / pharmacology* Secosteroids / chemistry Secosteroids / isolation & purification Secosteroids / pharmacology Steroids / chemistry Steroids / isolation & purification Steroids / pharmacology* |
| IF | 3.044 |
| Resource | |
| Human and Animal Cells | NB1RGB(RCB0222) |