Reference - Detail
| RRC ID | 61180 |
|---|---|
| Author | Chen X, Meng Y, Wang Y, Du C, Yang C. |
| Title | A Biomimetic Material with a High Bio-responsibility for Bone Reconstruction and Tissue Engineering. |
| Journal | J Biomater Sci Polym Ed |
| Abstract |
A biomimetic composite was prepared using type-I collagen as the matrix, and particles of sol-gel-derived bioactive glass (58S), hyaluronic acid and phosphatidylserine as additives. The material has an interconnected 3-D porous structure with a porosity > 85%. When incubated in simulated body fluid (SBF), the composite induced the formation of microcrystals of bone-like hydroxyapatite (HA), suggesting good bioactive properties. During the in vitro cell-culture experiment, MC3T3-E1 cells adhered to, migrated and spread on the surface of the porous composite. The material was employed to repair a 10-mm defect in a rabbit's radius. The composite was gradually degraded within 8 weeks and replaced by new bone. After 12 weeks, the bone marrow cavity was restored and the Haversian canal was noted from the histological observation. The biomimetic composite is a potential scaffold material for bone reconstruction and bone tissue engineering. |
| Volume | 22(1-3) |
| Pages | 153-63 |
| Published | 2011-1-1 |
| DOI | 10.1163/092050609X12583524936191 |
| PII | jbs3090 |
| PMID | 20546681 |
| MeSH | 3T3 Cells Absorbable Implants* Animals Biomimetic Materials* / chemistry Bone Regeneration Bone Substitutes* / chemistry Calcification, Physiologic Cell Adhesion Cell Movement Disease Models, Animal Durapatite / chemistry Glass* / chemistry Mice Microscopy, Electron, Scanning Porosity Rabbits Radius / injuries Spectrum Analysis Tissue Engineering / instrumentation Tissue Scaffolds* / chemistry X-Ray Diffraction |
| IF | 2.69 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |