論文 - 詳細
| RRC ID | 61246 |
|---|---|
| 著者 | Widyowati R, Tezuka Y, Miyahara T, Awale S, Kadota S. |
| タイトル | Alkaline phosphatase (ALP) enhancing iridoid glucosides from the Indonesian medicinal plant Barleria lupulina. |
| ジャーナル | Nat Prod Commun |
| Abstract |
In order to find antiosteoporotic agents from natural resources, 32 Indonesian medicinal plants were screened for their effects on osteoblast differentiation by using alkaline phosphatase (ALP) activity in MC3T3-E1 osteoblast cells as a marker. From the extract of Barleria lupulina, which showed the most potent activity, 13 iridoid glucosides, including three new ones [8-O-acetylipolamiidic acid (1), 8-O-acetyl-6-O-(p-methoxy-cis-cinnamoyl)shanzhiside (2), and 8-O-acetyl-6-O-(p-methoxy-trans-cinnamoyl)shanzhiside (3)] were identified. Among the 13 iridoid glucosides, ipolamiide (4) showed the most potent activity in a dose-dependent manner. |
| 巻・号 | 5(11) |
| ページ | 1711-6 |
| 公開日 | 2010-11-1 |
| PMID | 21213964 |
| MeSH | 3T3 Cells Acanthaceae / chemistry* Alkaline Phosphatase / metabolism* Animals Indonesia Iridoid Glucosides / chemistry* Iridoid Glucosides / pharmacology* Mice Molecular Structure Plants, Medicinal / chemistry* Structure-Activity Relationship |
| IF | 0.468 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |