Reference - Detail
| RRC ID | 61267 |
|---|---|
| Author | Inada M, Katagiri T, Akiyama S, Namika M, Komaki M, Yamaguchi A, Kamoi K, Rosen V, Suda T. |
| Title | Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Effects of bone morphogenetic protein (BMP)-12 and BMP-13, new members of the BMP family which belong to the transforming growth factor (TGF)-beta superfamily, on terminal differentiation of myoblasts were examined in C2C12 and L-6 myoblasts. When the myoblasts were cultured with BMP-12 or BMP-13, the expression of the myosin heavy chain and the formation of multinucleated myotubes mRNA in L-6 cells. The inhibitory effects of BMP-12 and BMP-13 on myogenic differentiation were similar to the effects of BMP-2, though their potencies were lower than BMP-2. Unlike BMP-2, neither BMP-12 nor BMP-13 induced alkaline phosphatase activity in C2C12 myoblasts. The differences in the biological activities of these new BMPs suggest that the intracellular signalling pathway used by BMP-12 and BMP-13 differs from that of BMP-2. |
| Volume | 222(2) |
| Pages | 317-22 |
| Published | 1996-5-15 |
| DOI | 10.1006/bbrc.1996.0742 |
| PII | S0006291X96907421 |
| PMID | 8670203 |
| MeSH | Alkaline Phosphatase / biosynthesis Animals Bone Morphogenetic Proteins Cell Differentiation / drug effects* Dose-Response Relationship, Drug Enzyme Induction Humans Kinetics Mice Muscle, Skeletal / cytology* Muscle, Skeletal / drug effects Myosin Heavy Chains / biosynthesis Osteoblasts / cytology* Osteoblasts / drug effects Proteins / pharmacology* RNA, Messenger / biosynthesis Recombinant Proteins / pharmacology Transforming Growth Factor beta / pharmacology |
| IF | 2.985 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ROS-17/2.8-5(RCB0462) |