論文 - 詳細
| RRC ID | 61283 |
|---|---|
| 著者 | Uto T, Tung NH, Taniyama R, Miyanowaki T, Morinaga O, Shoyama Y. |
| タイトル | Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa. |
| ジャーナル | Phytother Res |
| Abstract |
Recently, the resources of medicinal plants have been exhausting. The root of Angelica acutiloba is one of the most important ingredients in Japanese Kampo medicine for the treatment of gynecological diseases. In our search for alternative medicinal plant resources of the root of A. acutiloba, we found that its aerial part has the anti-inflammatory potency as well as the root. Phytochemical investigation of the aerial part resulted in the isolation of four compounds including a new dimeric phthalide, namely tokiaerialide (2), along with Z-ligustilide (1), falcarindiol (3), and bergaptol (4). Next, we investigated the in vitro anti-inflammatory activity of 1-4 in lipopolysaccharide-stimulated RAW264 macrophages. Among the isolated compounds, 1 exhibited the most potent inhibition against lipopolysaccharide-induced production of prostaglandin E2 , nitric oxide, and pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-α). Compounds 3 and 4 also inhibited all inflammatory mediators, but their inhibitory abilities were weaker than those of 1. Furthermore, 1, 3, and 4 strongly also induced heme oxygenase-1. These results suggest that 1, 3, and 4 potentially exert anti-inflammatory activity, and the aerial part of A. acutiloba may be considered to be a useful medicinal resource for inflammatory diseases. |
| 巻・号 | 29(12) |
| ページ | 1956-63 |
| 公開日 | 2015-12-1 |
| DOI | 10.1002/ptr.5490 |
| PMID | 26463105 |
| MeSH | 4-Butyrolactone / analogs & derivatives 4-Butyrolactone / isolation & purification 4-Butyrolactone / pharmacology Angelica / chemistry* Animals Anti-Inflammatory Agents / isolation & purification Anti-Inflammatory Agents / pharmacology* Benzofurans / isolation & purification Benzofurans / pharmacology* Dinoprostone / metabolism Diynes / isolation & purification Diynes / pharmacology Fatty Alcohols / isolation & purification Fatty Alcohols / pharmacology Furocoumarins / isolation & purification Furocoumarins / pharmacology Heme Oxygenase-1 / metabolism Interleukin-6 / metabolism Lipopolysaccharides Macrophages / drug effects Mice Molecular Structure Nitric Oxide / metabolism Phytochemicals / isolation & purification Phytochemicals / pharmacology* Plant Components, Aerial / chemistry* Plant Extracts / pharmacology Plant Roots / chemistry Plants, Medicinal / chemistry RAW 264.7 Cells Tumor Necrosis Factor-alpha / metabolism |
| IF | 4.087 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |