Reference - Detail
| RRC ID | 61345 |
|---|---|
| Author | Fujioka N, Ohashi K, Ikeda M, Kurimoto M. |
| Title | Autocrine interferon-beta stimulation augments nitric oxide production by mouse macrophage J774A.1 cells infected with herpes simplex virus type 1. |
| Journal | Microbiol Immunol |
| Abstract |
The pathogenic roles of nitric oxide (NO) in mouse models have been reported for herpes simplex virus type 1 (HSV-1)-induced pneumonia as well as endotoxin shock. We compared the mechanism of NO production induced by HSV-1 with that induced by lipopolysaccharide (LPS) using a mouse macrophage cell line, J774A.1. Both HSV-1 and LPS induced NO production as well as antiviral activity, which were attenuated by anti-interferon (IFN)-beta treatment. These results suggest that autocrine IFN-beta plays a role in NO release by J774A.1 cells stimulated with HSV-1 or LPS. |
| Volume | 44(4) |
| Pages | 283-7 |
| Published | 2000-1-1 |
| DOI | 10.1111/j.1348-0421.2000.tb02497.x |
| PMID | 10832974 |
| MeSH | Animals Antibodies / immunology Cell Line Dexamethasone / pharmacology Herpesvirus 1, Human / physiology* Interferon-beta / immunology Interferon-beta / pharmacology Interferon-beta / physiology* Lipopolysaccharides / pharmacology Macrophages / drug effects* Macrophages / metabolism Macrophages / virology* Mice Nitric Oxide / biosynthesis* |
| IF | 1.566 |
| Resource | |
| Human and Animal Cells | U251(RCB0461) |